Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.7708
Peer-review started: September 15, 2021
First decision: October 18, 2021
Revised: November 30, 2021
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: August 6, 2022
Processing time: 309 Days and 20.5 Hours
The factors influencing the prognosis of patients with esophageal cancer vary among studies and are still poorly known.
To determine the factors associated with survival in patients with esophageal cancer.
This retrospective study included patients with esophageal cancer admitted between January 2017 and March 2020 at Heping Hospital Affiliated to Changzhi Medical College. All patients were treated according to the available guidelines. Follow-up was censored in October 2020. Univariable and multivariable Cox regression analyses were used to determine the independent risk factors for overall survival (OS).
In total, 307 patients were included. Their median age was 64 (range, 44-79) years, 63.5% were male, and the median disease course was 2 (0.1-36) months. The median tumor size was 3 (0-10) cm. Most patients were T3 (29.6%), N0 (70.0%). Most tumors were grade 2 (48.2%), and 87.3% were squamous cell carcinoma. The in-hospital mortality was 16.9%, the 30-day mortality was 19.9%, and the 90-day mortality was 25.4%. The cumulative OS rates at the last follow-up were 82.1% (95%CI: 67.7%-96.5%) for stage 0/I/II and 47.4% (95%CI: 16.5-78.6%) for stage III/IVA (P < 0.001). The multivariable analysis showed that creatinine levels (HR = 1.02, 95%CI: 1.00-1.03, P = 0.050), pTNM III/IVA (HR = 4.19, 95%CI: 2.19-8.01, P < 0.001), adjuvant radiotherapy and/or chemotherapy (HR = 0.23, 95%CI: 0.11-0.49), and the Comprehensive Complication Index (CCI) (HR = 1.02, 95%CI: 1.004-1.03, P = 0.011) were independently associated with OS.
The survival of patients with esophageal cancer is poor, especially those with pTNM III/IVA. pTNM stage III/IVA, CCI, and adjuvant therapy (radiotherapy and/or chemotherapy) are independently associated with OS.
Core Tip: The factors influencing prognosis in esophageal cancer vary among studies and are still poorly known. Therefore, this study aimed to determine the factors related to the survival of patients with esophageal cancer. The results showed that the in-hospital mortality was 16.9%, the 30-day mortality was 19.9%, and the 90-day mortality was 25.4%. Hence, the survival of patients with esophageal cancer is poor, especially those with pTNM III/IVA disease. pTNM stage III/IVA, Comprehensive Complication Index, and adjuvant therapy (radiotherapy and/or chemotherapy) are independently associated with overall survival. These results help delineate the factors associated with poor survival in patients with esophageal cancer.