Fei HX, Qian CF, Wu XM, Wei YH, Huang JY, Wei LH. Role of micronutrients in Alzheimer's disease: Review of available evidence. World J Clin Cases 2022; 10(22): 7631-7641 [PMID: 36158513 DOI: 10.12998/wjcc.v10.i22.7631]
Corresponding Author of This Article
Jin-Yu Huang, MD, Director, Department of Neurology, The First Affiliated Hospital of Guangxi University of Science and Technology, No. 124 Yuejin Road, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China. lilin2169@163.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hong-Xin Fei, Chao-Fan Qian, Xiang-Mei Wu, Yu-Hua Wei, Li-Hua Wei, Department of Pathology, Guangxi University of Science and Technology, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China
Jin-Yu Huang, Department of Neurology, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China
Author contributions: Fei HX, Huang JY, and Wei LH had the idea for the article; Fei HX wrote the initial paper; Huang JY and Wei LH critically revised the paper; all authors performed the literature search and data analysis, read and approved the final manuscript.
Supported byGuangxi Zhuang Autonomous Region Natural Science Fund, No. 2020GXNSFAA297001; Guangxi Zhuang Autonomous Region Liuzhou Science and Technology Program Fund, No. 2020NBAA0805; Guangxi University of Technology, No. 20Z06; and Jiangxi Social Science Research and Planning Fund, No. 19JY34.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Yu Huang, MD, Director, Department of Neurology, The First Affiliated Hospital of Guangxi University of Science and Technology, No. 124 Yuejin Road, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China. lilin2169@163.com
Received: January 26, 2022 Peer-review started: January 26, 2022 First decision: March 23, 2022 Revised: April 29, 2022 Accepted: June 21, 2022 Article in press: June 21, 2022 Published online: August 6, 2022 Processing time: 176 Days and 23.5 Hours
Abstract
Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains known. Multiple factors are related to AD, such as genetic factors, aging, lifestyle, and nutrients. Both epidemiological and clinical evidence has shown that the levels of micronutrients, such as copper, zinc, and iron, are closely related to the development of AD. In this review, we summarize the roles of eight micronutrients, including copper, zinc, iron, selenium, silicon, manganese, arsenic, and vitamin D in AD based on recently published studies.
Core Tip: Significant advances have been made in characterizing the relationship between Alzheimer's disease (AD) and micronutrients copper, zinc, iron, selenium, silicon, manganese, and arsenic. This study provides a new perspective and direction for future scientific research, development of new drugs, and routine preventive measures against AD.
