Kim Y, Kim YS, Yoo JJ, Kim SG, Chin S, Moon A. Rare case of hepatocellular carcinoma metastasis to urinary bladder: A case report . World J Clin Cases 2022; 10(16): 5470-5478 [PMID: 35812687 DOI: 10.12998/wjcc.v10.i16.5470]
Corresponding Author of This Article
Young Seok Kim, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170, Jomaru-ro, Bucheon-si, Gyeonggi-do, Bucheon B1 420 02 02, Gyeonggi-do, South Korea. liverkys@schmc.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2022; 10(16): 5470-5478 Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5470
Rare case of hepatocellular carcinoma metastasis to urinary bladder: A case report
Yohan Kim, Young Seok Kim, Jeong-Ju Yoo, Sang Gyune Kim, Susie Chin, Ahrim Moon
Yohan Kim, Department of Gastroenterology, Soonchunhyang University Hospital Bucheon, Bucheon B1 420 02 02, Gyeonggi-do, South Korea
Young Seok Kim, Jeong-Ju Yoo, Sang Gyune Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon B1 420 02 02, Gyeonggi-do, South Korea
Susie Chin, Department of Pathology, Soonchunhyang University Bucheon Hospital, Bucheon B1 420 02 02, Gyeonggi-do, South Korea
Ahrim Moon, Department of Pathology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon B1 420 02 02, Gyeonggi-do, South Korea
Author contributions: Kim YS contributed to conceptualization, investigation, project administration, and writing—review & editing; Kim Y contributed to data curation; formal analysis, resources, visualization, and writing—original draft; Kim SG contributed to methodology; Yoo JJ contributed to supervision; all authors contributed to approval of final manuscript.
Informed consent statement: The requirement of informed written consent was waived by the Institutional Review Board (IRB) due to the retrospective nature of this case report.
Conflict-of-interest statement: The authors have no conflicts of interest relevant to this study to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016). The manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Young Seok Kim, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170, Jomaru-ro, Bucheon-si, Gyeonggi-do, Bucheon B1 420 02 02, Gyeonggi-do, South Korea. liverkys@schmc.ac.kr
Received: October 14, 2021 Peer-review started: October 14, 2021 First decision: December 17, 2021 Revised: January 18, 2022 Accepted: April 4, 2022 Article in press: April 4, 2022 Published online: June 6, 2022 Processing time: 230 Days and 23.4 Hours
Abstract
BACKGROUND
Hepatocellular carcinoma (HCC) is a primary liver cancer with high prevalence and mortality. There are many cases of advanced HCC at the time of diagnosis. Treatment methods and prognosis are different depends on whether metastasis is present. Thus, it is necessary to make an accurate evaluation at the time of diagnosis. Extrahepatic metastases of HCC usually occur through hematogenous spread or through adjacent organs such as the peritoneum. Metastasis to the urinary bladder alone is rare. Here, we report a rare case of biopsy-proven solitary metastasis of HCC to the bladder in a 60-year-old woman.
CASE SUMMARY
A 60-year-old female patient was found to be positive for hepatitis B surface antigen by chance after abdominal ultrasonography showed abnormal findings. Thus, liver dynamic computed tomography (CT) was performed. The patient visited the hospital for further examination. Ultrasound and CT showed 3.6 cm sized arterial enhancing mass in segment 5 and an infiltrative mass in segment 8. The patient was diagnosed with HCC through liver dynamic magnetic resonance imaging and liver biopsy. Afterwards, she underwent two transcatheter arterial chemoembolizations within five months for HCC. During follow-up, a newly appeared bladder tumor was found on liver dynamic CT. She underwent transurethral resection of the bladder tumor for diagnosis and treatment. The tissue was confirmed as metastatic HCC.
CONCLUSION
Although rare, metastasis to urinary bladder from HCC can occur without evidence of other distant metastases. Thus, regular follow-up imaging examination and clinical attention are required.
