Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2022; 10(15): 4971-4984
Published online May 26, 2022. doi: 10.12998/wjcc.v10.i15.4971
CD8-positive indolent T-Cell lymphoproliferative disorder of the gastrointestinal tract: A case report and review of literature
Chun-Yan Weng, Cheng Ye, Yi-Hong Fan, Bin Lv, Chun-Li Zhang, Meng Li
Chun-Yan Weng, Department of Gastroenterology, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Cheng Ye, Yi-Hong Fan, Bin Lv, Meng Li, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Chun-Li Zhang, Department of Pathology, The First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Weng CY, Fan YH reviewed the case; Li M and Weng CY wrote the manuscript; Lv B and Zhang CL edited the manuscript; all authors contributed to discussions and gave final approval of the submitted manuscript.
Informed consent statement: Written informed consent for publication of clinical details and/or clinical images was obtained from the patient. A copy of the consent form is available for review by the Editor of this journal.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng Li, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Street, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. lemon20050928@163.com
Received: October 21, 2021
Peer-review started: October 21, 2021
First decision: December 1, 2021
Revised: December 13, 2021
Accepted: April 3, 2022
Article in press: April 3, 2022
Published online: May 26, 2022
Abstract
BACKGROUND

Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI), a primary tumor forming in the gastrointestinal (GI) tract, represents a rarely diagnosed clonal T-cell disease with a protracted clinical course.

CASE SUMMARY

This report presented a 45-year-old male patient with a 6-year history of anal fistula and a more than 10-year history of recurrent diarrhea who was not correctly diagnosed until the occurrence of complications such as intestinal perforation. Postsurgical histopathological analysis, combined with hematoxylin-eosin staining, immunohistochemistry and TCRβ/γ clonal gene rearrangement test, confirmed the diagnosis of CD8+ ITLPD-GI.

CONCLUSION

Individuals with this scarce lymphoma frequently show non-specific symptoms that are hard to recognize. So far, indolent CD8+ ITLPD-GI has not been comprehensively examined. The current mini-review focused on evaluating indolent CD8+ ITLPD-GI cases based on existing literature and discussing future directions for improved differential diagnosis, detection of genetic and epigenetic alterations, and therapeutic target identification.

Keywords: Indolent T-cell lymphoproliferative disease, Gastrointestinal tract, Inflammatory bowel disease, Immunohistochemistry, Case report

Core Tip: Here we presented a case report of a patient with a history of anal fistula and chronic recurrent diarrhea. This case was easily misdiagnosed as inflammatory bowel disease, enteropathy associated T-cell lymphoma and other diseases due to the lack of characteristic manifestations, which posed great challenges to clinicians and pathologists.