Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2022; 10(15): 4843-4855
Published online May 26, 2022. doi: 10.12998/wjcc.v10.i15.4843
Psychosocial adaptation and influencing factors among patients with chemotherapy-induced peripheral neuropathy
Xiao Zhou, Dong-Yang Wang, Cai-Yan Ding, Hui Liu, Zhi-Qin Sun
Xiao Zhou, Changzhou School of Clinical Medicine, Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Dong-Yang Wang, Department of Nursing, School of Pharmacy, Changzhou University, Changzhou 213000, Jiangsu Province, China
Dong-Yang Wang, Faculty of Nursing, Mahidol University, Nakhon Pathom 73170, Thailand
Cai-Yan Ding, Zhi-Qin Sun, Department of Nursing, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Hui Liu, School of Nursing, Bengbu Medical College, Bengbu 233000, Jiangsu Province, China
Author contributions: Zhou X and Wang DY contributed equally to this work; Zhou X and Sun ZQ designed the research study; Zhou X, Ding CY, Liu H performed the research; Zhou X and Wang DY contributed new reagents and analytic tools; Zhou X, Wang DY, Ding CY analyzed the data and wrote the manuscript; All the authors have read and approved the manuscript.
Supported by the Nursing Research Project Funding by the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, No. 2020HZD003.
Institutional review board statement: The study was reviewed and approved by the Science and Research Office of Changzhou Second People’s Hospital (Changzhou).
Conflict-of-interest statement: The authors declared that no conflict of interest.
Data sharing statement: No data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Qin Sun, MM, RN, Dean, Professor, Department of Nursing, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Gehu Street, Changzhou 213000, Jiangsu Province, China. zqs1201@163.com
Received: December 11, 2021
Peer-review started: December 11, 2021
First decision: January 26, 2022
Revised: February 3, 2022
Accepted: March 27, 2022
Article in press: March 27, 2022
Published online: May 26, 2022
Processing time: 163 Days and 22.5 Hours
Abstract
BACKGROUND

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and long-lasting side effect caused by various anticancer agents that damage sensory, motor and autonomic nerves. It can cause maladaptive behaviors, including disease severity, anxiety, depression, sleep disorders, falls, and social impairment. These disorders have physical, psychological and social effects on patients and can seriously influence their quality of life.

AIM

To investigate the current situation of psychosocial adaptation to the disease and its influencing factor in patients with CIPN.

METHODS

A convenience sampling method was used to select 233 patients with CIPN in our hospital from February to August 2021. In addition, a cross-sectional survey was conducted using a sociodemographic questionnaire, the Self-Report Psychosocial Adjustment to Illness Scale, and the European Organisation for the Research and Treatment of Cancer Quality of Life CIPN20 (QLQ-CIPN20). Factors influencing psychosocial adaptation in patients with CIPN were analyzed by t-test or one-way analysis of variance, correlation analysis, multiple stepwise regression analysis, and structural equation models.

RESULTS

The psychosocial adaptation score of patients with CIPN was 52.51 ± 13.18. Multivariate analysis showed that autonomic nerves, tumor stage, motor nerves, education level, availability of caregivers, semi-retirement status, CIPN grade were independent risk factors for patients with CIPN (P < 0.05). Structural equation models showed that QLQ-CIPN20 mediated the relationship between CIPN grade, tumor stage, and psychosocial adaptation.

CONCLUSION

Patients with CIPN have poor psychosocial adaptation and are affected by a variety of physiological, psychological, and social factors. Patients’ adaptive responses should be assessed, and targeted interventions implemented.

Keywords: Chemotherapy-induced peripheral neuropathy; Cancer; Peripheral neurotoxicity; Psychosocial adaptation; Quality of life

Core Tip: The incidence of chemotherapy-induced peripheral neuropathy (CIPN) is approximately 47% after 6 years of treatment, which severely affects the level of patient adaptation. Most studies have focused on interventions to alleviate the symptoms of neurotoxicity in patients, but there has been less focus on psychosocial adaptation. In this study, we investigated the psychosocial adaptation of 233 patients with CIPN to analyze the factors influencing their psychosocial adaptation.