Li PH, Tang Y, Wen HZ. Qingchang decoction retention enema may induce clinical and mucosal remission in left-sided ulcerative colitis: A case report. World J Clin Cases 2022; 10(11): 3573-3578 [PMID: 35582052 DOI: 10.12998/wjcc.v10.i11.3573]
Corresponding Author of This Article
Hong-Zhu Wen, MD, Attending Doctor, Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. ellawhz@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 16, 2022; 10(11): 3573-3578 Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3573
Qingchang decoction retention enema may induce clinical and mucosal remission in left-sided ulcerative colitis: A case report
Pei-Han Li, Yu Tang, Hong-Zhu Wen
Pei-Han Li, Hong-Zhu Wen, Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Yu Tang, Department of Basic Medicine, Fudan University, Shanghai 200032, China
Author contributions: Li PH interpreted and reviewed the literature; Tang Y contributed to manuscript drafting and revision; Wen HZ was the patient’s attending doctor and was responsible for revising the manuscript for important intellectual content; all authors issued final approval of the version to be submitted.
Supported byNational Natural Science Foundation of China, No. 81703986.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Zhu Wen, MD, Attending Doctor, Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. ellawhz@sina.com
Received: November 8, 2021 Peer-review started: November 8, 2021 First decision: December 27, 2021 Revised: January 8, 2022 Accepted: February 27, 2022 Article in press: February 27, 2022 Published online: April 16, 2022 Processing time: 150 Days and 23.2 Hours
Abstract
BACKGROUND
Ulcerative colitis (UC) is a chronic autoimmune disease characterized by relapsing-remitting abdominal pain, diarrhea, mucopurulent discharge and rectal bleeding. To date, the etiology of the disease remains unknown; therefore, medical therapy is not yet available. Left-sided UC is mainly treated with oral and topical mesalazine. However, due to its modest clinical effect, endoscopic mucosal remission is not achieved in all patients.
CASE SUMMARY
A 44-year-old man presented to Longhua Hospital with a history of left-sided UC for more than 6 years and slight bloody diarrhea over time. Endoscopy suggested hyperemia, edema, and erosive mucosa involving the rectum and sigmoid colon. The Traditional Chinese medicine Qingchang decoction (QCD) enema treatment was initiated once a day combined with a previous standard dose of mesalazine for 8 wk, and rectal bleeding ceased after 4 wk of treatment. Another QCD enema treatment was provided after symptom relapse due to drug withdrawal for nearly 6 mo. At the 2-mo follow-up, the colonoscopy results indicated mucosal healing with no erosion or ulcers.
CONCLUSION
The Chinese formula QCD retention enema represents a potential treatment for left-sided UC with predominant rectal bleeding to achieve clinical and mucosal remission.
Core Tip: We present a case of a 44-year-old man with mildly active left-sided ulcerative colitis (UC) for 6 years in whom mesalazine treatment failed but clinical and mucosal remission was achieved following Chinese formula Qingchang decoction (QCD) retention enema treatment combined with oral mesalazine. Thus, a QCD enema may be an effective treatment modality for patients with left-sided UC.
