Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2022; 10(10): 3113-3120
Published online Apr 6, 2022. doi: 10.12998/wjcc.v10.i10.3113
Breast-conserving surgery and sentinel lymph node biopsy for breast cancer and their correlation with the expression of polyligand proteoglycan-1
Fu-Ming Li, Dan-Ying Xu, Qi Xu, Yan Yuan
Fu-Ming Li, Dan-Ying Xu, Qi Xu, Yan Yuan, Department of Breast Surgery, The Second Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Author contributions: Li FM and Xu DY contributed equally to this work and are considered co-first authors; Li FM and Xu DY analyzed and interpreted data and wrote the manuscript; Xu Q and Yuan Y drafted the manuscript and collected the data; Li FM designed the study and revised the manuscript for important intellectual content.
Supported by Jiaxing Science and Technology Project, No. 2021AD30119.
Institutional review board statement: The study was reviewed and approved by the Jiaxing Second Hospital Institutional Review Board (Approval No. JXEY-2021JX005).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Dr. Li FM reports grants from Jiaxing Science and Technology Project, during the conduct of the study. No other conflict-of-interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Ming Li, MHSc, Associate Chief Physician, Department of Breast Surgery, The Second Hospital of Jiaxing, No. 1518 Huancheng North Road, Nanhu District, Jiaxing 314000, Zhejiang Province, China. doclfm@163.com
Received: December 20, 2021
Peer-review started: December 20, 2021
First decision: January 18, 2022
Revised: February 6, 2022
Accepted: February 20, 2022
Article in press: February 20, 2022
Published online: April 6, 2022
Abstract
BACKGROUND

Breast cancer is a malignant tumor with an unclear etiology and is the most common malignant tumor in women. Surgery is the main clinical treatment for breast cancer. Although traditional total mastectomy combined with axillary lymph node dissection is effective, it can result in shoulder dysfunction, especially in middle-aged and elderly patients with breast cancer with weak constitution and other underlying diseases. Furthermore, the postoperative quality of life is poor.

AIM

To assess breast-conserving surgery and sentinel lymph node biopsy for breast cancer treatment and their correlation with polyligand proteoglycan-1.

METHODS

Overall, 80 patients with breast cancer treated in our hospital from January 2021 to July 2021 were retrospectively selected and divided into an observation group (n = 44) and control group (n = 36) according to the treatment plan. The observation group was treated with breast-conserving surgery and sentinel lymph node biopsy, and the control group was treated with total breast resection. Simultaneously, immunohistochemical staining was used to detect the expression of syndecan-1 (SDC-1) in the lesions, and its relationship with clinicopathological findings was analyzed.

RESULTS

Intraoperative blood loss, operation time, and hospital stay in the observation group were 65.51 ± 9.94 mL, 65.59 ± 9.40 min, and 14.80 ± 3.03 d, respectively, which were significantly lower than those in the control group (P < 0.05). The incidence of postoperative complications in the observation group was 11.36%, which was significantly lower than that in the control group (P < 0.05). The positive expression rate of SDC-1 in the observation group was 25.00%, and there was no significant difference between the groups (P > 0.05). The positive expression rate of SDC-1 in patients with American Joint Committee on Cancer (AJCC) stage II was 14.29%, which was significantly lower than that in patients with AJCC stage I (P < 0.05). The positive expression of SDC-1 had no significant relationship with age, course of disease, site, tissue type, and treatment plan (P > 0.05).

CONCLUSION

Breast preservation surgery and sentinel lymph node biopsy for breast cancer treatment have fewer complications and quicker recovery than those treated with total breast resection. Low SDC-1 expression in breast cancer lesions is related to AJCC staging.

Keywords: Breast preservation, Sentinel lymph node biopsy, Breast cancer, Clinical effectiveness, Polyligand proteoglycan-1

Core Tip: Breast preservation and sentinel lymph node biopsy has shown to have a good treatment effect in patients with breast cancer, especially in older patients, as well as the significant advantage of guaranteed postoperative quality of life for patients. Polyligand proteoglycan-1 is used as a cell surface mucin polysaccharide, which is also a kind of biological macromolecular protein closely associated with tumorigenesis. In this study, we explored the relationship between breast cancer treatment and polyligand proteoglycan-1 through this study.