Prospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2024; 16(4): 1149-1154
Published online Apr 27, 2024. doi: 10.4240/wjgs.v16.i4.1149
Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway
Li Han, Kun Tang, Xiao-Li Fang, Jing-Xi Xu, Xi-Yun Mao, Ming Li
Li Han, Department of Anorectal, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui Hospital, Hefei 230001, Anhui Province, China
Kun Tang, Xiao-Li Fang, Xi-Yun Mao, Ming Li, Anorectal Center, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230001, Anhui Province, China
Jing-Xi Xu, Department of Spleen and Stomach Diseases, Department of Gastroenterology, Affiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese Medicine, Wuhu 241000, Anhui Province, China
Author contributions: Han L and Li M contributed equally to this work; Han L, Tang K, Fang XL, Xu JX, Mao XY and Li M, designed the research study; Han L, Tang K, Fang XL, Xu JX, Mao XY and Li M performed the research; Han L, Tang K and Li M analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui Hospital Institutional Review Board (2022AH-022).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Dr. Li has nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming Li, MMed, Chief Physician, Anorectal Center, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, No. 103 Meishan Road, Shushan District, Hefei 230001, Anhui Province, China. lmys154@163.com
Received: January 12, 2024
Peer-review started: January 12, 2024
First decision: January 31, 2024
Revised: February 8, 2024
Accepted: March 7, 2024
Article in press: March 7, 2024
Published online: April 27, 2024
Core Tip

Core Tip: Kuicolong-yu enema decoction retains a traditional Chinese medicine enema that can prolong the remission period; however, there is not enough evidence to prove this. This prospective clinical study showed that Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates the inflammatory response of ulcerative colitis through the TLR4/NF-κB signaling pathway.