Published online Apr 27, 2024. doi: 10.4240/wjgs.v16.i4.1149
Peer-review started: January 12, 2024
First decision: January 31, 2024
Revised: February 8, 2024
Accepted: March 7, 2024
Article in press: March 7, 2024
Published online: April 27, 2024
Ulcer colitis (UC) is a chronic, nonspecific, and noninfectious inflammatory bowel disease. Recently, Toll-like receptors (TLRs) have been found to be closely associated with clinical inflammatory diseases. Achieving complete remission in patients with intermittent periods of activity followed by dormancy is challen
To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in UC.
This prospective clinical study included patients who met the exclusion criteria in 2020 and 2021. The patients with UC were divided into two groups (control and experimental). The peripheral blood of the experimental and control groups were collected under aseptic conditions. The expression of TLR4 protein, NF-κB, IL-6, and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the drug. Linear co
There were no significant differences in the patient characteristics between the control and experimental groups. The results showed that the expression levels of TLR4 and NF-κB in the experimental group were significantly lower than those in the control group (P < 0.05). The levels of IL-6 and IL-17 in the experimental group were significantly lower than those in the control group (P < 0.05). The TLR4 protein expression in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-17 (r = 0.823, P < 0.05).
Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates the inflammatory response of UC through the TLR4/NF-κB signaling pathway.
Core Tip: Kuicolong-yu enema decoction retains a traditional Chinese medicine enema that can prolong the remission period; however, there is not enough evidence to prove this. This prospective clinical study showed that Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates the inflammatory response of ulcerative colitis through the TLR4/NF-κB signaling pathway.