Published online Apr 27, 2024. doi: 10.4240/wjgs.v16.i4.1149
Peer-review started: January 12, 2024
First decision: January 31, 2024
Revised: February 8, 2024
Accepted: March 7, 2024
Article in press: March 7, 2024
Published online: April 27, 2024
Ulcer colitis (UC) is difficult to cure completely, with periods of remission, also called intermittent periods, followed by dormancy.
The Kuicolong-yu enema decoction is a traditional Chinese medicine enema that can prolong the remission period of UC, but there is not enough evidence to prove this.
To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in ulcerative.
Under aseptic conditions, peripheral blood samples were collected from both groups before and one month after drug administration. The expression levels of Toll-like receptor 4 (TLR4) protein, NF-κB, IL-6, and IL-17 were measured in the peripheral blood samples.
The results showed that the TLR4 and NF-κB expression levels in the experimental group were significantly lower than those in the control group. The IL-6 and IL-17 Levels in the experimental group were significantly lower than those in the control group. The expression of TLR4 protein in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-17.
Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates the inflammatory response of ulcerative colitis through the TLR4/NF-κB signaling pathway.
Kuicolong-yu enema decoction retains traditional Chinese medicine enemas, which are valuable in the treatment of ulcerative colitis.