Han L, Tang K, Fang XL, Xu JX, Mao XY, Li M. Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway. World J Gastrointest Surg 2024; 16(4): 1149-1154 [PMID: 38690048 DOI: 10.4240/wjgs.v16.i4.1149]
Corresponding Author of This Article
Ming Li, MMed, Chief Physician, Anorectal Center, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, No. 103 Meishan Road, Shushan District, Hefei 230001, Anhui Province, China. lmys154@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2024; 16(4): 1149-1154 Published online Apr 27, 2024. doi: 10.4240/wjgs.v16.i4.1149
Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway
Li Han, Kun Tang, Xiao-Li Fang, Jing-Xi Xu, Xi-Yun Mao, Ming Li
Li Han, Department of Anorectal, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui Hospital, Hefei 230001, Anhui Province, China
Kun Tang, Xiao-Li Fang, Xi-Yun Mao, Ming Li, Anorectal Center, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230001, Anhui Province, China
Jing-Xi Xu, Department of Spleen and Stomach Diseases, Department of Gastroenterology, Affiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese Medicine, Wuhu 241000, Anhui Province, China
Author contributions: Han L and Li M contributed equally to this work; Han L, Tang K, Fang XL, Xu JX, Mao XY and Li M, designed the research study; Han L, Tang K, Fang XL, Xu JX, Mao XY and Li M performed the research; Han L, Tang K and Li M analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui Hospital Institutional Review Board (2022AH-022).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Dr. Li has nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming Li, MMed, Chief Physician, Anorectal Center, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, No. 103 Meishan Road, Shushan District, Hefei 230001, Anhui Province, China. lmys154@163.com
Received: January 12, 2024 Peer-review started: January 12, 2024 First decision: January 31, 2024 Revised: February 8, 2024 Accepted: March 7, 2024 Article in press: March 7, 2024 Published online: April 27, 2024 Processing time: 101 Days and 7.1 Hours
ARTICLE HIGHLIGHTS
Research background
Ulcer colitis (UC) is difficult to cure completely, with periods of remission, also called intermittent periods, followed by dormancy.
Research motivation
The Kuicolong-yu enema decoction is a traditional Chinese medicine enema that can prolong the remission period of UC, but there is not enough evidence to prove this.
Research objectives
To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in ulcerative.
Research methods
Under aseptic conditions, peripheral blood samples were collected from both groups before and one month after drug administration. The expression levels of Toll-like receptor 4 (TLR4) protein, NF-κB, IL-6, and IL-17 were measured in the peripheral blood samples.
Research results
The results showed that the TLR4 and NF-κB expression levels in the experimental group were significantly lower than those in the control group. The IL-6 and IL-17 Levels in the experimental group were significantly lower than those in the control group. The expression of TLR4 protein in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-17.
Research conclusions
Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates the inflammatory response of ulcerative colitis through the TLR4/NF-κB signaling pathway.
Research perspectives
Kuicolong-yu enema decoction retains traditional Chinese medicine enemas, which are valuable in the treatment of ulcerative colitis.