Gostiljac DM, Popovic SS, Dimitrijevic-Sreckovic V, Ilic SM, Jevtovic JA, Nikolic DM, Soldatovic IA. Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients. World J Diabetes 2024; 15(4): 664-674 [PMID: 38680690 DOI: 10.4239/wjd.v15.i4.664]
Corresponding Author of This Article
Dragan M Nikolić, MD, PhD, Doctor, Research Associate, Science Editor, Faculty of Medicine, University of Belgrade, Dr Subotica 9, Belgrade 11000, Serbia. dragannikolic8@yahoo.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Apr 15, 2024; 15(4): 664-674 Published online Apr 15, 2024. doi: 10.4239/wjd.v15.i4.664
Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients
Drasko M Gostiljac, Srdjan S Popovic, Vesna Dimitrijevic-Sreckovic, Sasa M Ilic, Jelena A Jevtovic, Dragan M Nikolic, Ivan A Soldatovic
Drasko M Gostiljac, Srdjan S Popovic, Vesna Dimitrijevic-Sreckovic, Sasa M Ilic, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Drasko M Gostiljac, Srdjan S Popovic, Vesna Dimitrijevic-Sreckovic, Dragan M Nikolic, Ivan A Soldatovic, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Jelena A Jevtovic, Clinic for Gastroenterology and Hepatology, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Dragan M Nikolic, Clinic for Endocrinology, Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets Culture, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Author contributions: Gostiljac DM, Popovic SS and Dimitrijevic-Sreckovic V designed the research study; Gostiljac DM, Ilic SM and Jevtovic JA performed the research; Gostiljac DM, Soldatovic IA and Nikolic DM analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: All subjects provided informed consent for inclusion in the study. The investigation was carried out in accordance with the Declaration of Helsinki and was revised in 2013.
Clinical trial registration statement: The study is registered in the German Clinical Trials Register DRKS00023611. The clinical trial was registered after completion because the law of the Republic of Serbia does not require registration in the international registry.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: All authors agree that there is no conflict of interest.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dragan M Nikolić, MD, PhD, Doctor, Research Associate, Science Editor, Faculty of Medicine, University of Belgrade, Dr Subotica 9, Belgrade 11000, Serbia. dragannikolic8@yahoo.com
Received: November 26, 2023 Peer-review started: November 26, 2023 First decision: December 17, 2023 Revised: January 8, 2024 Accepted: March 7, 2024 Article in press: March 7, 2024 Published online: April 15, 2024 Processing time: 137 Days and 21.9 Hours
ARTICLE HIGHLIGHTS
Research background
Bread that we are testing is novel, tasty and very effective in populations with compromised glycoregulation. In our study, we compared novel bread with standard hospital rye bread and obtained significant differences regarding glucose metabolism of special type of bread (STB) with TopiGluk compared to rye bread.
Research motivation
All participants were given 50 g of rye bread or STB with herbal mixture on 2 consecutive days. In the continuation of these studies, it would be interesting to increase the amount of tested bread and see how it would affect postprandial glycemia.
Research objectives
To compare organoleptic characteristics of two sorts of bread and their effects on postprandial glucose and insulin levels in type 2 diabetes mellitus (T2DM) patients.
Research methods
Postprandial blood glucose and insulin levels were examined on 2 consecutive days after the consumption of rye bread and a special type of bread with an herbal mixture. A questionnaire was used for comparison of the organoleptic properties of two kinds of bread.
Research results
A special type of bread with an herbal mixture caused significantly lower postprandial blood glucose in T2DM patients than rye bread, and it showed better organoleptic and satiety characteristics.
Research conclusions
Our study showed a significant difference in postprandial blood glucose and insulin levels between patients that consumed rye bread and those that consumed a special type of bread with herbal mixture. This special type of bread has better effects on postprandial glucoregulation in T2DM patients.
Research perspectives
The results of this research can be the basis and incentive for future research that would determine which biochemical substances from plant components added to STB are responsible for the effect of postprandial glycemia.
