Gostiljac DM, Popovic SS, Dimitrijevic-Sreckovic V, Ilic SM, Jevtovic JA, Nikolic DM, Soldatovic IA. Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients. World J Diabetes 2024; 15(4): 664-674 [PMID: 38680690 DOI: 10.4239/wjd.v15.i4.664]
Corresponding Author of This Article
Dragan M Nikolić, MD, PhD, Doctor, Research Associate, Science Editor, Faculty of Medicine, University of Belgrade, Dr Subotica 9, Belgrade 11000, Serbia. dragannikolic8@yahoo.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Apr 15, 2024; 15(4): 664-674 Published online Apr 15, 2024. doi: 10.4239/wjd.v15.i4.664
Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients
Drasko M Gostiljac, Srdjan S Popovic, Vesna Dimitrijevic-Sreckovic, Sasa M Ilic, Jelena A Jevtovic, Dragan M Nikolic, Ivan A Soldatovic
Drasko M Gostiljac, Srdjan S Popovic, Vesna Dimitrijevic-Sreckovic, Sasa M Ilic, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Drasko M Gostiljac, Srdjan S Popovic, Vesna Dimitrijevic-Sreckovic, Dragan M Nikolic, Ivan A Soldatovic, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Jelena A Jevtovic, Clinic for Gastroenterology and Hepatology, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Dragan M Nikolic, Clinic for Endocrinology, Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets Culture, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Author contributions: Gostiljac DM, Popovic SS and Dimitrijevic-Sreckovic V designed the research study; Gostiljac DM, Ilic SM and Jevtovic JA performed the research; Gostiljac DM, Soldatovic IA and Nikolic DM analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: All subjects provided informed consent for inclusion in the study. The investigation was carried out in accordance with the Declaration of Helsinki and was revised in 2013.
Clinical trial registration statement: The study is registered in the German Clinical Trials Register DRKS00023611. The clinical trial was registered after completion because the law of the Republic of Serbia does not require registration in the international registry.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: All authors agree that there is no conflict of interest.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dragan M Nikolić, MD, PhD, Doctor, Research Associate, Science Editor, Faculty of Medicine, University of Belgrade, Dr Subotica 9, Belgrade 11000, Serbia. dragannikolic8@yahoo.com
Received: November 26, 2023 Peer-review started: November 26, 2023 First decision: December 17, 2023 Revised: January 8, 2024 Accepted: March 7, 2024 Article in press: March 7, 2024 Published online: April 15, 2024 Processing time: 137 Days and 21.9 Hours
Abstract
BACKGROUND
Nutrition recommendations in patients with type 2 diabetes mellitus (T2DM) are to consume rye or integral bread instead of white bread. A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin, so we formulated an herbal mixture that can be used as a supplement for a special type of bread (STB) to achieve better effects on postprandial glucose and insulin levels in patients with T2DM.
AIM
To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2DM patients.
METHODS
This trial included 97 patients with T2DM. A parallel group of 16 healthy subjects was also investigated. All participants were given 50 g of rye bread and the same amount of a STB with an herbal mixture on 2 consecutive days. Postprandial blood glucose and insulin levels were compared at the 30th, 60th, 90th and 120th min. A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of bread.
RESULTS
Compared to patients who consumed rye bread, significantly lower postprandial blood glucose and insulin concentrations were found in T2DM patients who consumed STB. No relevant differences were found among the healthy subjects. Subjectively estimated organoleptic and satiety characteristics are better for STB than for rye bread.
CONCLUSION
STB have better effects than rye bread on postprandial glucoregulation in T2DM patients. Subjectively estimated organoleptic and satiety characteristics are better for STB than for rye bread. Therefore, STB can be recommended for nutrition in T2DM patients.
Core Tip: We are testing special types of bread in populations with compromised glucoregulation. It is novel, tasty, and very effective in postprandial glucoregulation. In this study, we compared novel bread (TopiGluk) with standard hospital rye bread and obtained significant differences regarding glucose metabolism of TopiGluk compared to rye bread. This research might be interesting for readers because TopiGluk could become a standard supplement in bread for patients with compromised glucoregulation and those at high risk for diabetes.
