Overgrowth of Lactobacillus in gastric cancer

Table 1 Relative abundance of Lactobacillus from category I studies

Ref.	HC (n)	GC (n)	Lactobacillus	Fold change	LDA score
Gunathilake et al[17]	88	268	-
Gunathilake et al[18]	288	268	+	47.6	3.2
Cavadas et al[19]	164	83	-

HC: Healthy controls; GC: Gastric cancer; “+”: Significantly statistical difference between groups; “-“: No significant difference between groups.

Table 2 Changes in relative abundance of Lactobacillus from category II studies

Ref.	Control group (n)	GC group (n)	Lactobacillus	Fold change	LDA score
Jo et al[20]	29 (NC)	34	-
Sohn et al[21]	5 (NC)	7	+	194.6/1.9
Wang et al[16]	6 (CG)	6	+
Ferreira et al[22]	81 (CG)	54	+	188.0	4.4
Hu et al[23]	5 (CG)	6	-
Wu et al[24]	32 (SG)	18	+	2.5	> 2.4
Wang et al[10]	60 (CG)	60	-		> 3.6
Castaño-Rodríguez et al[25]	20 (FD)	12	+	17.7	3.6
Spiegelhauer et al[26]	22 (FD)	12	+	148.1

NC: Non-cancer; CG: Chronic gastritis; SG: Superficial gastritis; FD: Functional dyspepsia.

Table 3 Variations in relative abundance of Lactobacillus from category III studies

Ref.	HC	SG	AG	IM	IN	GC	Lactobacillus	Fold change (GC vs SG/CG)	LDA score
Aviles-Jimenez et al[27]		5		5		5	+
Eun et al[28]		10		10		11	-
Li et al[29]	8	9		9		7	-
Coker et al[30]		21	23	17		20	+
Hsieh et al[11]		9		7		11	+	81.0/91.1
Wang et al[14]	30	21		27	25	29	+	22.0	4.1
Dang et al[31]		17		13		30	-
Gantuya et al[32]	20	20	40	40		48	+	17.9	4.4

HC: Healthy controls; SG: Superficial gastritis; AG: Atrophy gastritis; IM: Intestinal metaplasia; IN: Intraepithelial neoplasia; GC: Gastric cancer.