Li ZP, Liu JX, Lu LL, Wang LL, Xu L, Guo ZH, Dong QJ. Overgrowth of Lactobacillus in gastric cancer. World J Gastrointest Oncol 2021; 13(9): 1099-1108 [PMID: 34616515 DOI: 10.4251/wjgo.v13.i9.1099]
Corresponding Author of This Article
Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. allyking114@126.com
Research Domain of This Article
Microbiology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Peng Li, Lin-Lin Lu, Li-Li Wang, Lin Xu, Quan-Jiang Dong, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong Province, China
Ju-Xin Liu, Clinical Laboratories, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China
Zong-Hao Guo, Department of Clinical Medicine, Jining Medical University, Jining 272000, Shandong Province, China
Author contributions: Li ZP and Guo ZH collected the literature; Li ZP and Lu LL analyzed the data and wrote the manuscript; Liu JX, Wang LL, and Xu L reviewed the literature and wrote the discussion part of the manuscript; Dong QJ designed the research and supervised the manuscript; all authors reviewed the manuscript and approved the final version of the manuscript.
Supported byThe National Natural Science Foundation of China, No. 31870777.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. allyking114@126.com
Received: February 22, 2021 Peer-review started: February 22, 2021 First decision: April 19, 2021 Revised: April 30, 2021 Accepted: July 23, 2021 Article in press: July 23, 2021 Published online: September 15, 2021 Processing time: 200 Days and 4.5 Hours
Abstract
Dysbiosis of the gastric microbiome is involved in the development of gastric cancer (GC). A number of studies have demonstrated an increase in the relative abundance of Lactobacillus in GC. In this review, we present data that support the overgrowth of Lactobacillus in GC from studies on molecular and bacterial culture of the gastric microbiome, discuss the heterogenic effects of Lactobacillus on the health of human stomach, and explore the potential roles of the overgrowth of Lactobacillus in gastric carcinogenesis. Further studies are required to examine the association between Lactobacillus and GC at strain and species levels, which would facilitate to elucidate its role in the carcinogenic process.
Core Tip: Many strains of Lactobacillus have been used as probiotics in the clinical setting. However, recent molecular analyses of the gastric microbiome demonstrate a close association between an increased abundance of Lactobacillus and gastric cancer. In this paper, we review the current understanding of heterogenic effects of Lactobacillus on the health of the human stomach and discuss potential roles of the overgrowth of Lactobacillus in the gastric carcinogenesis.
