Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2021; 13(9): 1099-1108
Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.1099
Overgrowth of Lactobacillus in gastric cancer
Zhi-Peng Li, Ju-Xin Liu, Lin-Lin Lu, Li-Li Wang, Lin Xu, Zong-Hao Guo, Quan-Jiang Dong
Zhi-Peng Li, Lin-Lin Lu, Li-Li Wang, Lin Xu, Quan-Jiang Dong, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong Province, China
Ju-Xin Liu, Clinical Laboratories, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China
Zong-Hao Guo, Department of Clinical Medicine, Jining Medical University, Jining 272000, Shandong Province, China
Author contributions: Li ZP and Guo ZH collected the literature; Li ZP and Lu LL analyzed the data and wrote the manuscript; Liu JX, Wang LL, and Xu L reviewed the literature and wrote the discussion part of the manuscript; Dong QJ designed the research and supervised the manuscript; all authors reviewed the manuscript and approved the final version of the manuscript.
Supported by The National Natural Science Foundation of China, No. 31870777.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China.
Received: February 22, 2021
Peer-review started: February 22, 2021
First decision: April 19, 2021
Revised: April 30, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: September 15, 2021
Core Tip

Core Tip: Many strains of Lactobacillus have been used as probiotics in the clinical setting. However, recent molecular analyses of the gastric microbiome demonstrate a close association between an increased abundance of Lactobacillus and gastric cancer. In this paper, we review the current understanding of heterogenic effects of Lactobacillus on the health of the human stomach and discuss potential roles of the overgrowth of Lactobacillus in the gastric carcinogenesis.