Clinical significance of expression of fibrous sheath interacting protein 1 in colon cancer

Table 1 Correlation between fibrous sheath interacting protein 1 expression and clinicopathological features (n = 302), n (%)

Characteristic (%)	FSIP1 negative (n = 203)	FSIP1 positive (n = 99)	P value
Median age	63 ± 17.6	59 ± 20.8	0.521
Sex
Male	121 (60)	54 (55)	0.438
Female	82 (40)	45 (45)
Tumor size			0.313
< 5	85 (41)	39 (39)
5-10	97 (48)	49 (49)
> 10	21 (5)	11 (12)
Pathological tumor stage			0.0011
T1	89 (44)	30 (30)
T2	46 (23)	17 (17)
T3	44 (22)	25 (25)
T4	24 (11)	27 (28)
Pathological nodal stage			0.0001
N0	65 (32)	20 (20)
N1	78 (38)	33 (33)
N2	39 (19)	28 (28)
N3	21 (11)	18 (19)
Tumor differentiation			0.0001
Well	71 (35)	45 (46)
Moderate	85 (42)	31 (31)
Poor	47 (23)	23 (23)

¹The results were statistically significant (P < 0.01). The results showed that high expression of fibrous sheath interacting protein 1 was positively correlated with colon cancer stage and lymph node metastasis and negatively correlated with tumour differentiation. FSIP1: Fibrous sheath interacting protein 1.

Table 2 Correlation between fibrous sheath interacting protein 1 expression and various clinicopathological factors

Clinicopathological parameter	P value (Spearman correlation)
Age	0.689 (0.055)
Sex	0.762 (0.047)
Tumour size	0.564 (0.061)
Pathological tumour stage	0.003 (0.476)1
Pathological nodal stage	0.001 (0.564)1
Tumour differentiation	0.001 (-0.595)2

¹Spearman correlation coefficient greater than 0, P < 0.05.

²Spearman correlation coefficient less than 0, P < 0.05. FSIP1: Fibrous sheath interacting protein 1.

Table 3 Relative mortality risk (n = 302) based on univariate and multivariate Cox regression analyses of clinical pathological parameters and high fibrous sheath interacting protein 1 expression

Characteristic	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age		0.899		0.675
≤ 60	1 (Ref)		1 (Ref)
> 60	0.972 (0.721-1.322)	0.899	1.019 (0.732–1.418)	0.675
Sex		0.674		0.739
Male	1 (Ref)		1 (Ref)
Female	1.558 (0.731-2.235)	0.674	2.339 (0.610-3.886)	0.739
Tumor size		0.003		0.219
< 5	1 (Ref)		1 (Ref)
5-10	1.427 (0.973-1.886)	0.043	1.339 (0.921-1.992)	0.198
> 10	1.661 (1.095-2.291)	0.005	1.431 (0.695-1.832)	0.399
Pathological tumor stage		0.000
T1	1 (Ref)		1 (Ref)	0.000
T2	2.521 (1.567-4.631)	0.001	1.330 (1.009-2.461)	0.002
T3	3.213 (2.288–9.198)	0.000	3.445 (1.925-4.901)	0.000
T4	4.883 (1.528–5.438)	0.000	4.870 (2.062-9.126)	0.000
Pathological nodal stage		0.000		0.000
N0	1 (Ref)		1 (Ref)
N1	1.916 (1.379-3.221)	0.003	1.687 (1.563-6.019)	0.002
N2	4.422 (1.837-7.622)	0.000	6.819 (3.421-12.567)	0.000
N3	9.230 (4.399-12.257)	0.000	7.909 (3.963-16.878)	0.000
Tumor differentiation		0.000		0.000
Well	1 (Ref)		1 (Ref)
Mediate	4.696 (1.565-8.912)	0.000	5.229 (4.442-9.887)	0.000
Poor	7.129 (3.126-11.703)	0.000	6.443 (2.126-12.556)	0.000
FSIP1 expression
Negative	1 (Ref)		1 (Ref)
Positive	2.933 (2.067-4.559)	0.000	2.661 (1.979-5.635)	0.001

The results showed that the hazard ratio of fibrous sheath interacting protein 1 positivity in terms of risk of death was 2.933 (95%CI: 2.067-4.559; P = 0.001). After adjusting for other baseline parameters (including age, sex, tumour size, pathological T stage, lymph node metastasis N stage, and tumour differentiation), the hazard ratio of fibrous sheath interacting protein 1 positivity in terms of risk of death changed minimally (hazard ratio = 2.661, 95%CI: 1.979-5.635; P = 0.001). CI: Confidence interval; HR: Hazard ratio; Ref: Reference category.