Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2020; 12(6): 677-686
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.677
Clinical significance of expression of fibrous sheath interacting protein 1 in colon cancer
Hui-Ying Wu, Bin Yang, Dong-Hua Geng
Hui-Ying Wu, Bin Yang, Department of Nursing, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Dong-Hua Geng, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wu HY, Yang B, and Geng DH contributed to the writing and revising of the manuscript.
Institutional review board statement: The study was approved by the Ethics committee of Shengjing Hospital of China Medical University.
Informed consent statement: Informed written consent was obtained from the patients.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The manuscript was revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dong-Hua Geng, MD, PhD, Associate Professor, Department of General Surgery, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. gdh024@163.com
Received: February 24, 2020
Peer-review started: February 24, 2020
First decision: March 24, 2020
Revised: April 11, 2020
Accepted: May 5, 2020
Article in press: May 5, 2020
Published online: June 15, 2020
Processing time: 112 Days and 2.2 Hours
Abstract
BACKGROUND

The occurrence and development of colon cancer are complex, involving a variety of genetic changes, such as mutation and activation of oncogenes, inactivation of tumour suppressor genes, and aberrant proliferation and apoptosis regulation mechanisms. Fibrous sheath interacting protein 1 (FSIP1) is a newly discovered oncogene that is frequently activated in a variety of tumours such as breast cancer and bladder cancer. However, the clinical significance of FSIP1 in colon cancer is unclear. In this study, we analysed the clinical significance of expression of FSIP1 in human colon cancer, aimed to clarify the biological role of FSIP1 in the development and progression of colon cancer.

AIM

To investigate the clinical significance of expression of FSIP1 in colon cancer.

METHODS

From March 2011 to March 2014, 302 specimens of tumour tissues and paracancerous tissues were obtained from patients pathologically diagnosed with colon cancer at Shengjing Hospital of China Medical University. Immunohistochemistry was used to detect FSIP1 expression in colon cancer tissues and adjacent normal tissues. Spearman correlation coefficient and Cox regression analyses were used to determine the relationship between FSIP1 expression and clinicopathological factors and prognosis, as well as the impact on survival.

RESULTS

Compared with its expression in adjacent normal tissues, FSIP1 was expressed at higher levels in colon cancer tissues. Spearman correlation analysis showed that high expression of FSIP1 was positively correlated with clinicopathological stage, lymph node metastasis, and poor prognosis in colon cancer; it was negatively correlated with the degree of tumour differentiation. Cox regression analysis showed that high FSIP1 expression was an independent risk factor for the prognosis of colon cancer patients.

CONCLUSION

High expression of FSIP1 may be one of the important factors affecting the clinical outcome of colon cancer patients and leading to poor prognosis.

Keywords: Colon cancer; Fibrous sheath-interacting protein 1; Expression; Prognosis; Clinical significance; Survival

Core tip: This study examined the expression of fibrous sheath interacting protein 1 (FSIP1) in 302 patients with colon carcinoma and analysed the follow-up data. The results showed that FSIP1 expression was not correlated with sex, age, tumour size, or other factors but was positively correlated with tumour pathological T/N stages and negatively correlated with tumour differentiation. Univariate and multivariate Cox regression analyses and survival analysis showed that high expression of FSIP1 was an independent risk factor for poor prognosis, and overall survival was worse in the FSIP1-high expression group than in the FSIP1-low expression group. So we speculate that FSIP1 plays a role in the carcinogenesis of colon cancer.