Perineural invasion of hilar cholangiocarcinoma in Chinese population: One center’s experience

Table 1 Reported series with perineural invasion in hilar cholangiocarcinoma

Ref.	Number of patient	Number of PNI (%)	Recurrence after curative resection (%)
Hu et al[1], 2019	258	38.8 (100/258)	70 (180/258)
Kovalenko et al[2], 2018	49	83.3 (41/49)	-
Ercolani et al[4], 2010	51	75 (33/44)	-
Young et al[5], 2010	51	92 (47/51)	-
Aishima et al[6], 2007	38	76.3 (29/38)	57.9 (22/38)
Robles et al[7], 2004	36	64 (23/36)	53.0 (19/36)
Nakagohri et al[9], 2003	26	100 (26/26)	-
Seyama et al[10], 2003	58	84.5 (49/58)	-
Nimura et al[11], 2000	42	59.2 (84142)	53.7 (58/108)
Nagakawa et al[12], 2000	47	92.5 (43/47)	-
Kurosaki et al[13], 1998	83	88 (73/83)	-
Yamaguchi et al[14], 1997	24	75 (18/24)	-
Su et al[15], 1996	49	73.5 (36/49)	-

PNI: Perineural invasion.

Table 2 Clinicopathologic characteristics of patients

Characteristics	n (%)
Gender
Female	33 (44)
Male	42 ( 56)
Bismuth-Corlette classification
Type I	19 (25.33)
Type II	20 (26.67)
Type III	20 (26.67)
Type IV	16 (21.33)
Histological differentiation
Well	9 (12)
Moderate	35 (46.67)
Poor	29 (38.67)
Mucinous	2 (2.67)
Lymphatic invasion
No	54 (72)
Yes	21 (28)
Depth of tumor invasion
Within bile duct serosa	2 (2.67)
Beyond bile duct serosa	73 (97.33)
Perineural invasion
No	6 (8)
Yes	69 (92)