Li CG, Zhou ZP, Tan XL, Zhao ZM. Perineural invasion of hilar cholangiocarcinoma in Chinese population: One center’s experience. World J Gastrointest Oncol 2020; 12(4): 457-466 [PMID: 32368323 DOI: 10.4251/wjgo.v12.i4.457]
Corresponding Author of This Article
Cheng-Gang Li, MD, PhD, Associate Professor, Second Department of Hepatobiliary Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. lcgang301@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Cheng-Gang Li, Zhi-Peng Zhou, Xiang-Long Tan, Zhi-Ming Zhao, Second Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Li CG and Zhou ZP contributed equally to this work, Zhou ZP considered as co-first authors; Li CG and Zhou ZP analyzed and interpreted data and wrote the article; Zhao ZZ and Tan XL drafted the work and collected the data.
Institutional review board statement: The study was approved by the Institutional Review Board of the Chinese PLA General Hospital (S2016-098-02).
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cheng-Gang Li, MD, PhD, Associate Professor, Second Department of Hepatobiliary Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. lcgang301@126.com
Received: December 23, 2019 Peer-review started: December 23, 2019 First decision: January 19, 2020 Revised: January 29, 2020 Accepted: February 17, 2020 Article in press: February 17, 2020 Published online: April 15, 2020 Processing time: 114 Days and 11.7 Hours
Core Tip
Core tip: The aim of this study was to summarize the incidence of perineural invasion (PNI) in hilar cholangiocarcinoma (HCCA), and provide the distribution of nerve plexuses around hepatic portal to clinical surgeons. Totally 75 patients with HCCA were investigated to summarize the incidence and modes of PNI. Sections of hepatoduodenal ligament from 5 autopsy cases were scanned to display the distribution of nerve plexuses around hepatic portal. The overall incidence of PNI in this study was 92% and three nerve plexuses in the hepatoduodenal ligament and Glisson’s sheath were classified and they all surrounded the great vessels very closely. PNI is grossly underreported in HCCA and it should be considered when stratifying HCCA patients for further adjuvant treatment.
