Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

Table 4 Univariate and multivariate analyses of overall survival of 321 gastric cancer patients in older group (age > 70 yr)

Characteristic	Univariate	Analysis	Multivariate	Analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex (Male/Female)	1.016 (0.742-1.392)	0.920
Hospitalization (≥ 18/< 18 mo)	1.328 (0.991-1.780)	0.058
T stage (3 + 4/1 + 2)	4.356 (2.709-7.003)	< 0.001
N stage (1-3/0)	3.690 (2.544-5.352)	< 0.001
M stage (1/0)	5.142 (3.210-8.237)	< 0.001
TNM (III-IV/I-II)	5.462 (3.723-8.001)	< 0.001	3.873 (2.571-5.836)	< 0.001
Location (Cardia/non-cardia)	1.314 (0.955-1.807)	0.094
Tumor size (≥ 4/< 4 cm)	2.711 (1.854-3.963)	< 0.001	1.468 (0.965-2.232)	0.073
Histological type (Diffuse/Intestinal)	1.675 (1.264-2.220)	< 0.001	1.441 (1.078-1.928)	0.014
Neural invasion (Y/N)	1.928 (1.392-2.671)	< 0.001	1.191 (0.828-1.713)	0.347
Vessel invasion (Y/N)	1.983 (1.464-2.684)	< 0.001	1.299 (0.927-1.822)	0.129
Esophageal invasion (Y/N)	2.602 (1.716-3.944)	< 0.001	2.330 (1.505-3.607)	<0.001
NLR (≥ 2.6/< 2.6)	1.554 (1.174-2.056)	0.002	1.396 (1.038-1.880)	0.028
Anemia (Y/N)	1.336 (0.999-1.785)	0.051
PLR (≥ 133/< 133)	1.221 (0.913-1.633)	0.179
Low albumin (Y/N)	1.420 (1.060-1.904)	0.019	1.121 (0.792-1.587)	0.519
Low prealbumin (Y/N)	1.781 (1.336-2.374)	< 0.001	1.190 (0.857-1.653)	0.299
PNI (< 47/≥ 47)	1.589 (1.179-2.142)	0.002	0.962 (0.659-1.404)	0.840

TNM: Tumor–node–metastasis; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet lymphocyte ratio; PNI: Prognostic nutritional index.