Copyright
©The Author(s) 2016.
World J Gastrointest Oncol. Aug 15, 2016; 8(8): 592-598
Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.592
Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.592
Figure 1 Main WNT/β-catenin pathway involved in cancer and stem cells.
Wnt inhibits CTNNB1 phosphorylation by GSK3B, which leads to the transcription of pro-proliferation related genes via binding of CTNNB1 to TCF or LEF. P indicates phosphate. Red color shows molecules in pathways in cancer, whereas blue color shows molecules in signaling pathways regulating pluripotency of stem cells (KEGG). DVL: Dishevelled; TCF: T cell transcription factor; APC: Adenomatous polyposis coli.
- Citation: Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Regulation of CTNNB1 signaling in gastric cancer and stem cells. World J Gastrointest Oncol 2016; 8(8): 592-598
- URL: https://www.wjgnet.com/1948-5204/full/v8/i8/592.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v8.i8.592