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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2016; 8(8): 592-598
Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.592
Regulation of CTNNB1 signaling in gastric cancer and stem cells
Shihori Tanabe, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki
Shihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan
Kazuhiko Aoyagi, Hiroki Sasaki, Department of Translational Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan
Hiroshi Yokozaki, Department of Pathology, Kobe University of Graduate School of Medicine, Kobe 650-0017, Japan
Author contributions: Tanabe S wrote the paper; Aoyagi K, Yokozaki H and Sasaki H contributed critical revisions of the manuscript for important intellectual content.
Conflict-of-interest statement: The authors declare that no conflicts of interest exist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shihori Tanabe, PhD, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, 1-18-1, Kami-yoga, Setagaya-ku, Tokyo 158-8501, Japan. stanabe@nihs.go.jp
Telephone: +81-3-37001141 Fax: +81-3-37076950
Received: March 7, 2016
Peer-review started: March 7, 2016
First decision: April 18, 2016
Revised: April 22, 2016
Accepted: May 17, 2016
Article in press: May 27, 2016
Published online: August 15, 2016
Processing time: 154 Days and 15.5 Hours
Core Tip

Core tip: CTNNB1 signaling is essential for revealing cancer mechanisms. The molecular dynamism in stem cells and cancer is illustrated with a pathway cascade. The CTNNB1 protein interacts with signaling molecules upon stimulation, leading to the transcription of genes related to cell proliferation. Mutations of signaling molecules are also important factors for cancer development. CTNNB1 signaling in stem cells and cancer are mainly described in the article.