Structure and function of Septin 9 and its role in human malignant tumors

doi:10.4251/wjgo.v12.i6.619

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2020; 12(6): 619-631
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.619

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Figure 1 Specific structural characteristics and biological functions of Septin 9. A: Octamers formed by mammalian septin complexes; B: Function and role of Septin 9 in human malignant tumors. SEPT9: Septin 9; HIF-1: Hypoxia inducible factor-1; JNK: Jun N-terminal kinase.

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Figure 2 Structure of the filaments containing Septins 7/9b/11 and Jun N-terminal kinase signaling pathway. A: Structure of the filaments containing Septins 7/9b/11; B: Regulatory mechanism of Septin 9 in the development and progression of malignant tumors. HIF-1: Hypoxia inducible factor-1; JNK: Jun N-terminal kinase; EMT: Epithelial-mesenchymal transformation; MLL: Mixed-lineage leukemia.

Citation: Sun J, Zheng MY, Li YW, Zhang SW. Structure and function of Septin 9 and its role in human malignant tumors. World J Gastrointest Oncol 2020; 12(6): 619-631
URL: https://www.wjgnet.com/1948-5204/full/v12/i6/619.htm
DOI: https://dx.doi.org/10.4251/wjgo.v12.i6.619