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World J Gastrointest Oncol. Jun 15, 2020; 12(6): 619-631
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.619
Structure and function of Septin 9 and its role in human malignant tumors
Jie Sun, Min-Ying Zheng, Yu-Wei Li, Shi-Wu Zhang
Jie Sun, Min-Ying Zheng, Shi-Wu Zhang, Department of Pathology, Tianjin Union Medical Center, Tianjin 300121, China
Yu-Wei Li, Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China
Author contributions: All authors contributed equally to this manuscript with conception and design of the study, literature review and analysis, manuscript drafting, critical revision, and editing, and final approval of the submission.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shi-Wu Zhang, MD, PhD, Academic Research, Chief Doctor, Director, Department of Pathology, Tianjin Union Medical Center, Jieyuan Road, Hongqiao District, Tianjin 300071, China. 30117012@nankai.edu.cn
Received: February 17, 2020
Peer-review started: February 17, 2020
First decision: March 24, 2020
Revised: April 3, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: June 15, 2020
Processing time: 117 Days and 0.4 Hours
Abstract

The treatment and prognosis of malignant tumors are closely related to the time when the tumors are diagnosed; the earlier the diagnosis of the tumor, the better the prognosis. However, most tumors are not detected in the early stages of screening and diagnosis. It is of great clinical significance to study the correlation between multiple pathogeneses of tumors and explore simple, safe, specific, and sensitive molecular indicators for early screening, diagnosis, and prognosis. The Septin 9 (SEPT9) gene has been found to be associated with a variety of human diseases, and it plays a role in the development of tumors. SEPT9 is a member of the conserved family of cytoskeletal GTPase, which consists of a P-loop-based GTP-binding domain flanked by a variable N-terminal region and a C-terminal region. SEPT9 is involved in many biological processes such as cytokinesis, polarization, vesicle trafficking, membrane reconstruction, deoxyribonucleic acid repair, cell migration, and apoptosis. Several studies have shown that SEPT9 may serve as a marker for early screening, diagnosis, and prognosis of some malignant tumors, and have the potential to become a new target for anti-cancer therapy. This article reviews the progress in research on the SEPT9 gene in early screening, diagnosis, and prognosis of tumors.

Keywords: Septin 9; Malignant tumor; Early diagnosis; Prognosis; Deoxyribonucleic acid methylation; Colorectal cancer

Core tip: The Septin 9 (SEPT9) gene has been found to be associated with a variety of human diseases, and it plays a role in the development of tumors. SEPT9 is a member of the conserved family of cytoskeletal GTPase. SEPT9 is involved in many biological processes such as cytokinesis, polarization, vesicle trafficking, membrane reconstruction, deoxyribonucleic acid repair, cell migration, and apoptosis. Several studies have shown that SEPT9 may serve as a marker for early screening, diagnosis, and prognosis of some malignant tumors, and have the potential to become a new target for anti-cancer therapy. This article reviews the progress in research on the SEPT9 gene in early screening, diagnosis, and prognosis of tumors.