Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection

Figure 1 Violin plots showing the preoperative systemic immune-inflammation index level stratified by (A) status of hepatolithiasis, (B) tumor size, (C) tumor number, (D) status of lymph node invasion, and (E) TNM stage. ^aP < 0.05; ^bP < 0.01; ^eP < 0.001. SII: Systemic immune-inflammation index; TNM: Tumor-node-metastasis according to the 8^th edition of the American Joint Committee on Cancer Staging Manual.

Figure 2 Kaplan-Meier curves for overall survival and recurrence-free survival stratified by systemic immune-inflammation index (A and D), neutrophil-to-lymphocyte ratio (B and E) and platelet-to-lymphocyte ratio (C and F) in the derivation cohort. SII: Systemic immune-inflammation index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.

Figure 3 Kaplan-Meier curves for overall survival and recurrence-free survival stratified by systemic immune-inflammation index (A and D), neutrophil-to-lymphocyte ratio (B and E) and platelet-to-lymphocyte ratio (C and F) in the validation cohort. SII: Systemic immune-inflammation index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.

Figure 4 Subgroup analyses for overall survival based on clinicopathologic features in the entire cohort. SII: Systemic immune-inflammation index.

Figure 5 Subgroup analyses for recurrence-free survival based on clinicopathologic features in the entire cohort. SII: Systemic immune-inflammation index.