Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2020; 12(4): 467-482
Published online Apr 15, 2020. doi: 10.4251/wjgo.v12.i4.467
Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection
Hui Li, Jin-Ju Wang, Min Zhang, Bo Ren, Jia-Xin Li, Lin Xu, Hong Wu
Hui Li, Jin-Ju Wang, Bo Ren, Jia-Xin Li, Lin Xu, Hong Wu, Department of Liver Surgery and Liver Transplantation, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Hui Li, Jin-Ju Wang, Bo Ren, Jia-Xin Li, Lin Xu, Hong Wu, State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, Sichuan Province, China
Hui Li, Jin-Ju Wang, Bo Ren, Jia-Xin Li, Lin Xu, Hong Wu, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China
Min Zhang, Department of Anesthesiology, Jiulongpo People’s Hospital, Chongqing 400000, China
Author contributions: Li H, Wang JJ and Zhang M contributed equally to this work and should be considered as co-first authors; Li H and Wu H contributed to the designation of this study; Li H and Xu L collected the clinical data; Li H, Wang JJ and Ren B contributed to data analysis; Li H and Li JX performed the statistical analysis; all the authors participated in drafting the manuscript; Li H, Wang JJ and Zhang M revised the manuscript; all the authors approved the final version of manuscript.
Supported by the National Natural Science Foundation of China, No. 81972747, No. 81872004, No. 81800564, No. 81770615, No. 81700555 and No. 81672882; the Science and Technology Support Program of Sichuan Province, No. 2019YFQ0001, No. 2018SZ0115 and No. 2017SZ0003; the Science and Technology Program of Tibet Autonomous Region, No. XZ201801-GB-02; and the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, No. ZYJC18008.
Institutional review board statement: This study was approved by Institutional Review Board of the West China Hospital.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: All the authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong Wu, MD, PhD, Professor, Surgeon, Department of Liver Surgery and Liver Transplantation, West China Hospital of Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. wuhong7801@163.com
Received: December 13, 2019
Peer-review started: December 13, 2019
First decision: February 14, 2020
Revised: March 11, 2020
Accepted: March 26, 2020
Article in press: March 26, 2020
Published online: April 15, 2020
Processing time: 123 Days and 23.8 Hours
Core Tip

Core tip: Inflammation has been reported to play a crucial role in tumor biology. Systemic immune-inflammation index (SII), an inflammation-based index, was a composite measure of neutrophil, platelet and lymphocyte counts. No data exists until now, has evaluated its prognostic value for intrahepatc cholangiocarcinoma (ICC). This study aimed to investigate the clinical significance of preoperative SII levels in ICC patients undergoing curative resection. Patients with increased SII level were associated with worse overall survival and earlier tumor recurrence. In the future, the SII could help stratifying patients with ICC, thus guiding therapeutic choices, especially in immunotherapy.