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World J Gastrointest Oncol. Aug 15, 2015; 7(8): 111-117
Published online Aug 15, 2015. doi: 10.4251/wjgo.v7.i8.111
Inflammation-based factors and prognosis in patients with colorectal cancer
Kiyoshi Maeda, Masatusne Shibutani, Hiroshi Otani, Hisashi Nagahara, Tetsuro Ikeya, Yasuhito Iseki, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa
Kiyoshi Maeda, Masatusne Shibutani, Hiroshi Otani, Hisashi Nagahara, Tetsuro Ikeya, Yasuhito Iseki, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: There is no financial support or relationships that may pose any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kiyoshi Maeda, MD, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. m1378386@med.osaka-cu.ac.jp
Telephone: +81-66-6453838 Fax: +81-66-6466450
Received: January 14, 2015
Peer-review started: January 16, 2015
First decision: April 24, 2015
Revised: April 30, 2015
Accepted: July 7, 2015
Article in press: July 8, 2015
Published online: August 15, 2015
Processing time: 212 Days and 7.4 Hours
Core Tip

Core tip: Recently, it has become clear that an elevated systemic inflammatory response is consistently associated with a poor outcome, independent of the tumor stage. The inflammatory response is represented by the levels of serum neutrophils, lymphocytes and platelet s as well as acute-phase proteins and their combinations. These parameters are simple and easy to measure using widely available standardized assays. In this review, we discuss the prognostic value of various inflammation-based factors in patients with colorectal cancer.