Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 104455
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.104455
Importance of hematological and inflammatory markers in the localization of gastric cancer
Süleyman Dolu, Mehmet B Cengiz, Hüseyin Döngelli, Mustafa Gürbüz, Mehmet E Arayici
Süleyman Dolu, Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, İzmir 35340, Türkiye
Mehmet B Cengiz, Department of Internal Medicine, Ağrı Training and Research Hospital, Ağrı 04000, Türkiye
Hüseyin Döngelli, Department of Internal Medicine, Dokuz Eylul Universitesy, İzmir 35330, Türkiye
Mustafa Gürbüz, Department of Medical Oncology, Ağrı Training and Research Hospital, Ağrı 04000, Türkiye
Mehmet E Arayici, Department of Biostatistics and Medical Informatics, Faculty of Medicine, İzmir 35330, Türkiye
Author contributions: Dolu S designed the study, acquired funding and wrote the original draft; Dolu S, Gürbüz M, and Cengiz MB were responsible for developing the methodology; Döngelli H and Arayici ME participated in the formal analysis and investigation; Dolu S, Cengiz MB, Döngelli H, Gürbüz M, and Arayici ME participated in the review and editing.
Institutional review board statement: This study was approved by the Ağrı Training and Research Hospital Scientific Research Ethics Committee (No. E-95531838-050.99-86900) and conducted in accordance with the Declaration of Helsinki.
Informed consent statement: Signed informed consent was obtained from all participants.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Süleyman Dolu, Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, İnciraltı Mahallesi Mithatpaşa cad. no:1606 Balçova/İzmir, İzmir 35340, Türkiye. suleyman.dolu@deu.edu.tr
Received: December 25, 2024
Revised: January 20, 2025
Accepted: February 7, 2025
Published online: April 15, 2025
Processing time: 95 Days and 4.6 Hours
Core Tip

Core Tip: This study highlights the distinct clinical and laboratory profiles of proximal and distal gastric cancers. The platelet-to-lymphocyte ratio was identified as a significant marker for differentiating cancer localization, while the neutrophil-to-lymphocyte ratio emerged as an independent predictor of all-cause mortality. These findings emphasize the potential of hematological and inflammatory markers in improving diagnostic precision and guiding personalized treatment strategies for gastric cancer.