Dolu S, Cengiz MB, Döngelli H, Gürbüz M, Arayici ME. Importance of hematological and inflammatory markers in the localization of gastric cancer. World J Gastrointest Oncol 2025; 17(4): 104455 [DOI: 10.4251/wjgo.v17.i4.104455]
Corresponding Author of This Article
Süleyman Dolu, Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, İnciraltı Mahallesi Mithatpaşa cad. no:1606 Balçova/İzmir, İzmir 35340, Türkiye. suleyman.dolu@deu.edu.tr
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 104455 Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.104455
Importance of hematological and inflammatory markers in the localization of gastric cancer
Süleyman Dolu, Mehmet B Cengiz, Hüseyin Döngelli, Mustafa Gürbüz, Mehmet E Arayici
Süleyman Dolu, Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, İzmir 35340, Türkiye
Mehmet B Cengiz, Department of Internal Medicine, Ağrı Training and Research Hospital, Ağrı 04000, Türkiye
Hüseyin Döngelli, Department of Internal Medicine, Dokuz Eylul Universitesy, İzmir 35330, Türkiye
Mustafa Gürbüz, Department of Medical Oncology, Ağrı Training and Research Hospital, Ağrı 04000, Türkiye
Mehmet E Arayici, Department of Biostatistics and Medical Informatics, Faculty of Medicine, İzmir 35330, Türkiye
Author contributions: Dolu S designed the study, acquired funding and wrote the original draft; Dolu S, Gürbüz M, and Cengiz MB were responsible for developing the methodology; Döngelli H and Arayici ME participated in the formal analysis and investigation; Dolu S, Cengiz MB, Döngelli H, Gürbüz M, and Arayici ME participated in the review and editing.
Institutional review board statement: This study was approved by the Ağrı Training and Research Hospital Scientific Research Ethics Committee (No. E-95531838-050.99-86900) and conducted in accordance with the Declaration of Helsinki.
Informed consent statement: Signed informed consent was obtained from all participants.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Süleyman Dolu, Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, İnciraltı Mahallesi Mithatpaşa cad. no:1606 Balçova/İzmir, İzmir 35340, Türkiye. suleyman.dolu@deu.edu.tr
Received: December 25, 2024 Revised: January 20, 2025 Accepted: February 7, 2025 Published online: April 15, 2025 Processing time: 94 Days and 23.6 Hours
Abstract
BACKGROUND
Gastric cancer is a major global health concern, often diagnosed at advanced stages, leading to poor prognosis. Proximal and distal gastric cancers exhibit distinct clinicopathological features.
AIM
To investigate the diagnostic value of hematological and inflammatory markers in differentiating proximal and distal gastric cancers and to evaluate their association with clinical outcomes.
METHODS
A retrospective cohort study was conducted on 150 patients diagnosed with gastric adenocarcinoma through histopathological analysis. Patients were categorized into proximal gastric cancer and distal gastric cancer groups. Laboratory parameters were analyzed.
RESULTS
Of the 150 patients, 84 had proximal gastric cancer and 66 had distal gastric cancer. Dysphagia was significantly more common in the proximal gastric cancer group, while anemia and higher platelet-to-lymphocyte ratio values were observed in the distal gastric cancer group (P = 0.031). Tumor stage and neutrophil-to-lymphocyte ratio emerged as independent predictors of all-cause mortality. No significant differences were found in other laboratory or biochemical parameters between the groups.
CONCLUSION
Proximal and distal gastric cancers demonstrate distinct clinical and laboratory profiles. The platelet-to-lymphocyte ratio may serve as a valuable marker in differentiating cancer localization, while the neutrophil-to-lymphocyte ratio is a prognostic indicator for mortality. These findings highlight the potential of hematological markers in optimizing diagnosis and treatment strategies for gastric cancer.
Core Tip: This study highlights the distinct clinical and laboratory profiles of proximal and distal gastric cancers. The platelet-to-lymphocyte ratio was identified as a significant marker for differentiating cancer localization, while the neutrophil-to-lymphocyte ratio emerged as an independent predictor of all-cause mortality. These findings emphasize the potential of hematological and inflammatory markers in improving diagnostic precision and guiding personalized treatment strategies for gastric cancer.
