Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 99673
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.99673
Pharmacological role of Herba Patriniae and Coix seed in colorectal cancer
Yu-Xin Zhang, Hui Wan, Guan-Yue Shan, Jun-Ya Cheng, Yi-Ying Liu, Wen-Na Shi, Hai-Jun Li
Yu-Xin Zhang, Hui Wan, Guan-Yue Shan, Yi-Ying Liu, Wen-Na Shi, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Jun-Ya Cheng, Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130061, Jilin Province, China
Hai-Jun Li, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Author contributions: Zhang YX, Wan H, Shan GY and Shi WN collected the information; Cheng JY and Liu YY drew and modified the illustrations; Zhang YX wrote the paper; Li HJ revised the paper; all of the authors read and approved the final version of the manuscript to be published.
Supported by National Natural Science Foundation of China, No. 81970529; and The Natural Science Foundation of Jilin Province, No. 20230508074RC and No. YDZJ202401218ZYTS.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn
Received: July 27, 2024
Revised: October 31, 2024
Accepted: December 25, 2024
Published online: March 15, 2025
Processing time: 201 Days and 21.6 Hours
Core Tip

Core Tip: Colorectal cancer (CRC) can be treated with novel chemotherapeutic agents combining traditional Chinese medicine (TCM) and herbal extracts in addition to traditional treatments including radiotherapy, chemotherapy, surgery and cytotoxic drugs. The TCMs Herba Patriniae and Coix seed can act on the signaling pathways of CRC, such as phosphoinositide 3 kinase/Akt/mammalian target of rapamycin, p53, transforming growth factor-β/SMAD, NFkappaB and Wnt/β-catenin, to show better therapeutic effect, and their future treatments and applications in CRC are very valuable and promising.