Zhang YX, Wan H, Shan GY, Cheng JY, Liu YY, Shi WN, Li HJ. Pharmacological role of Herba Patriniae and Coix seed in colorectal cancer. World J Gastrointest Oncol 2025; 17(3): 99673 [DOI: 10.4251/wjgo.v17.i3.99673]
Corresponding Author of This Article
Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yu-Xin Zhang, Hui Wan, Guan-Yue Shan, Yi-Ying Liu, Wen-Na Shi, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Jun-Ya Cheng, Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130061, Jilin Province, China
Hai-Jun Li, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Author contributions: Zhang YX, Wan H, Shan GY and Shi WN collected the information; Cheng JY and Liu YY drew and modified the illustrations; Zhang YX wrote the paper; Li HJ revised the paper; all of the authors read and approved the final version of the manuscript to be published.
Supported by National Natural Science Foundation of China, No. 81970529; and The Natural Science Foundation of Jilin Province, No. 20230508074RC and No. YDZJ202401218ZYTS.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn
Received: July 27, 2024 Revised: October 31, 2024 Accepted: December 25, 2024 Published online: March 15, 2025 Processing time: 201 Days and 21.6 Hours
Abstract
Colorectal cancer (CRC) is the most prevalent cancer globally, and its traditional treatment modalities commonly encompass radiation therapy, chemotherapy, surgery and the administration of cytotoxic drugs. Currently, novel chemotherapy drugs that combine traditional Chinese medicine (TCM) with herbal extracts exhibit superior comprehensive benefits. Herein, we delved into an article authored by Wang et al, focusing specifically on the pharmacological effects of "Herba Patriniae and Coix seed (HC)" and their targeted mechanisms in combating CRC. From the perspective of TCM philosophy, damp-heat stagnation and toxicity are the cardinal pathogenic factors underlying CRC. HC, renowned for their abilities to antipyretic and enhance diuresis, have demonstrated promising efficacy in preliminary studies for the treatment of CRC. These findings offer potential insights in favor of fostering anti-cancer medications.
Core Tip: Colorectal cancer (CRC) can be treated with novel chemotherapeutic agents combining traditional Chinese medicine (TCM) and herbal extracts in addition to traditional treatments including radiotherapy, chemotherapy, surgery and cytotoxic drugs. The TCMs Herba Patriniae and Coix seed can act on the signaling pathways of CRC, such as phosphoinositide 3 kinase/Akt/mammalian target of rapamycin, p53, transforming growth factor-β/SMAD, NFkappaB and Wnt/β-catenin, to show better therapeutic effect, and their future treatments and applications in CRC are very valuable and promising.
