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World J Gastrointest Oncol. May 15, 2024; 16(5): 1725-1736
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.1725
Advances in the study of gastric organoids as disease models
Yi-Yang Liu, De-Kun Wu, Ji-Bing Chen, You-Ming Tang, Feng Jiang
Yi-Yang Liu, Graduate School, Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
De-Kun Wu, Teaching Experiment and Training Center, Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Ji-Bing Chen, Central Laboratory, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
You-Ming Tang, Department of Digestive Disease, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Feng Jiang, AIDS Research Center, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Co-first authors: Yi-Yang Liu and De-Kun Wu.
Co-corresponding authors: Ji-Bing Chen and You-Ming Tang.
Author contributions: Liu YY designed the article framework and drafted the manuscript; Jiang F and Wu DK contributed equally to this work; Chen JB and Tang YM critically revised the manuscript for basic intellectual content; all authors have read and approved the final manuscript.
Supported by Chinese Medicine Service System and Capacity Building (Key Project with Chinese Medicine Characteristics and Advantages, Ruikang Hospital, 2023); and Guangxi Science and Technology Major Project during the 14th five-year Plan, No. Guike AA22096028.
Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-Bing Chen, MD, Doctor, Central Laboratory, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, No. 10 Huadong Road, Xingning District, Nanning 530011, Guangxi Zhuang Autonomous Region, China. jibingchen398@163.com
Received: December 18, 2023
Peer-review started: December 18, 2023
First decision: January 10, 2024
Revised: January 23, 2024
Accepted: March 25, 2024
Article in press: March 25, 2024
Published online: May 15, 2024
Processing time: 143 Days and 0.9 Hours
Core Tip

Core Tip: This paper provides a comprehensive summary and analysis of the advances in culture methods and techniques for adult stem cells, induced pluripotent stem cell-derived organoids and patient tumor-derived organoids. The potential value of gastric organoids in the study of the pathogenesis of gastric-related diseases, drug screening, and individualized treatment of gastric cancer patients is preliminarily discussed. Such research will provide better solutions for the treatment of stomach-related diseases and personalized medicine.