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World J Gastrointest Oncol. Mar 15, 2024; 16(3): 643-652
Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.643
Prognostic and predictive role of immune microenvironment in colorectal cancer
Olesya Kuznetsova, Mikhail Fedyanin, Larisa Zavalishina, Larisa Moskvina, Olga Kuznetsova, Alexandra Lebedeva, Alexey Tryakin, Galina Kireeva, Gleb Borshchev, Sergei Tjulandin, Ekaterina Ignatova
Olesya Kuznetsova, Mikhail Fedyanin, Alexey Tryakin, Sergei Tjulandin, Department of Chemotherapy, Federal State Budgetary Institution (N.N. Blokhin National Medical Research Center of Oncology) of the Ministry of Health of the Russian Federation, Moscow 115478, Russia
Larisa Zavalishina, Larisa Moskvina, Olga Kuznetsova, Department of Pathology, Russian Medical Academy of Continuous Professional Education, Moscow 123242, Russia
Alexandra Lebedeva, OncoAtlas LCC, Moscow 115478, Russia
Galina Kireeva, Gleb Borshchev, Federal State Budgetary Institution “National Medical and Surgical Center named after N.I. Pirogov” of the Ministry of Health of the Russian Federation, Moscow 105203, Russia
Ekaterina Ignatova, STOONCO: Science and Technology in Oncology, Moscow 115478, Russia
Author contributions: Kuznetsova O and Lebedeva A drafted the manuscript; Zavalishina L, Moskvina L, Kuznetsova O, and Kireeva G performed the literature search; Fedyanin M, Tryakin A, Borshchev G, Tjulandin S, and Ignatova E critically reviewed the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Olesya Kuznetsova, MD, Academic Research, Doctor, Department of Chemotherapy, Federal State Budgetary Institution (N.N. Blokhin National Medical Research Center of Oncology) of the Ministry of Health of the Russian Federation, 23 Kashirskoye Highway, Moscow 115478, Russia. kuznetsova.o.md@gmail.com
Received: November 23, 2023
Peer-review started: November 23, 2023
First decision: December 6, 2023
Revised: December 20, 2023
Accepted: January 22, 2024
Article in press: January 22, 2024
Published online: March 15, 2024
Processing time: 110 Days and 2.8 Hours
Core Tip

Core Tip: Here, we describe the current data and perspectives of integrating the immune microenvironment in risk assessment and treatment strategies of colorectal cancer. The identification of tumors with immunoscore showing sensitivity to immunotherapy provide insights into future clinical research.