Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4456-4467
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4456
Impact and mechanism study of dioscin on biological characteristics of colorectal cancer cells
Xie-Xiao Cai, Zhen-Feng Huang, Fu-Yang Tu, Jie Yu
Xie-Xiao Cai, Zhen-Feng Huang, Fu-Yang Tu, Jie Yu, Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Author contributions: Cai XX and Yu J initiated research and conducted data collection; Huang ZF and Tu FY recorded, organized data, and conducted statistical analysis; Cai XX and Yu J wrote the original manuscript and revised the paper; all authors read and approved the final manuscript.
Institutional review board statement: This study did not involve any human or animal experiment.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Yu, BMed, Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No. 108 Wansong Road, Wenzhou 325200, Zhejiang Province, China. 15968760998@163.com
Received: August 1, 2024
Revised: September 11, 2024
Accepted: September 29, 2024
Published online: November 15, 2024
Processing time: 85 Days and 2.3 Hours
Core Tip

Core Tip: This study investigates the anticancer effects of dioscin on colorectal cancer (CRC) cells (HCT116). Our findings reveal that dioscin inhibits cell viability, promotes apoptosis, and suppresses migration and invasion by modulating the Notch1 signaling pathway. These results highlight the potential of dioscin as a therapeutic agent against CRC.