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Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4354-4368
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4354
Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer
Run-Zhi Deng, Xin Zheng, Zhong-Lei Lu, Ming Yuan, Qi-Chang Meng, Tao Wu, Yu Tian
Run-Zhi Deng, Xin Zheng, Zhong-Lei Lu, College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China
Ming Yuan, Department of Hepatobiliary Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Qi-Chang Meng, Department of General Surgery, Peking University First Hospital, Beijing 100034, China
Tao Wu, Department of General Surgery, West China Hospital of Sichuan University, Chengdu 610044, Sichuan Province, China
Yu Tian, Department of Thoracic Surgery, Yancheng No. 1 People’s Hospital, Affiliated Hospital of Nanjing University Medical School, The First People’s Hospital of Yancheng, Yancheng 224000, Jiangsu Province, China
Author contributions: Deng RZ wrote the manuscript; Zheng X, Lu ZL, Yuan M, Meng QC, and Wu T collected the data; Tian Y guided the study. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Tian, Doctor, Department of Thoracic Surgery, Yancheng No. 1 People’s Hospital, Affiliated Hospital of Nanjing University Medical School, The First People’s Hospital of Yancheng, No. 166 Yulong Road, Yancheng 224000, Jiangsu Province, China. tianyujsyc@163.com
Received: July 23, 2024
Revised: August 24, 2024
Accepted: September 9, 2024
Published online: November 15, 2024
Processing time: 93 Days and 18.4 Hours
Core Tip

Core Tip: The role of colorectal cancer stem cells in the tumor immune microenvironment, the development and metastasis of colorectal cancer. This paper focuses on how colorectal cancer stem cells affect the tumor immune microenvironment through immune escape, immunosuppression and microenvironment remodeling, and analyzes their key functions in tumor progression and metastasis. In addition, this paper also summarizes potential therapeutic strategies for colorectal cancer stem cells, aiming to inhibit their cancer-promoting effects and provide new targets and ideas for the treatment of colorectal cancer.