Deng RZ, Zheng X, Lu ZL, Yuan M, Meng QC, Wu T, Tian Y. Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer. World J Gastrointest Oncol 2024; 16(11): 4354-4368 [PMID: PMC11551631 DOI: 10.4251/wjgo.v16.i11.4354]
Corresponding Author of This Article
Yu Tian, Doctor, Department of Thoracic Surgery, Yancheng No. 1 People’s Hospital, Affiliated Hospital of Nanjing University Medical School, The First People’s Hospital of Yancheng, No. 166 Yulong Road, Yancheng 224000, Jiangsu Province, China. tianyujsyc@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4354-4368 Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4354
Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer
Run-Zhi Deng, Xin Zheng, Zhong-Lei Lu, Ming Yuan, Qi-Chang Meng, Tao Wu, Yu Tian
Run-Zhi Deng, Xin Zheng, Zhong-Lei Lu, College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China
Ming Yuan, Department of Hepatobiliary Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Qi-Chang Meng, Department of General Surgery, Peking University First Hospital, Beijing 100034, China
Tao Wu, Department of General Surgery, West China Hospital of Sichuan University, Chengdu 610044, Sichuan Province, China
Yu Tian, Department of Thoracic Surgery, Yancheng No. 1 People’s Hospital, Affiliated Hospital of Nanjing University Medical School, The First People’s Hospital of Yancheng, Yancheng 224000, Jiangsu Province, China
Author contributions: Deng RZ wrote the manuscript; Zheng X, Lu ZL, Yuan M, Meng QC, and Wu T collected the data; Tian Y guided the study. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Tian, Doctor, Department of Thoracic Surgery, Yancheng No. 1 People’s Hospital, Affiliated Hospital of Nanjing University Medical School, The First People’s Hospital of Yancheng, No. 166 Yulong Road, Yancheng 224000, Jiangsu Province, China. tianyujsyc@163.com
Received: July 23, 2024 Revised: August 24, 2024 Accepted: September 9, 2024 Published online: November 15, 2024 Processing time: 93 Days and 18.4 Hours
Abstract
The relevant mechanism of tumor-associated macrophages (TAMs) in the treatment of colorectal cancer patients with immune checkpoint inhibitors (ICIs) is discussed, and the application prospects of TAMs in reversing the treatment tolerance of ICIs are discussed to provide a reference for related studies. As a class of drugs widely used in clinical tumor immunotherapy, ICIs can act on regulatory molecules on cells that play an inhibitory role - immune checkpoints - and kill tumors in the form of an immune response by activating a variety of immune cells in the immune system. The sensitivity of patients with different types of colorectal cancer to ICI treatment varies greatly. The phenotype and function of TAMs in the colorectal cancer microenvironment are closely related to the efficacy of ICIs. ICIs can regulate the phenotypic function of TAMs, and TAMs can also affect the tolerance of colorectal cancer to ICI therapy. TAMs play an important role in ICI resistance, and making full use of this target as a therapeutic strategy is expected to improve the immunotherapy efficacy and prognosis of patients with colorectal cancer.
Core Tip: The role of colorectal cancer stem cells in the tumor immune microenvironment, the development and metastasis of colorectal cancer. This paper focuses on how colorectal cancer stem cells affect the tumor immune microenvironment through immune escape, immunosuppression and microenvironment remodeling, and analyzes their key functions in tumor progression and metastasis. In addition, this paper also summarizes potential therapeutic strategies for colorectal cancer stem cells, aiming to inhibit their cancer-promoting effects and provide new targets and ideas for the treatment of colorectal cancer.
