Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1556-1566
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1556
MicroRNA-363-3p inhibits colorectal cancer progression by targeting interferon-induced transmembrane protein 1
Yun Wang, Shao-Kai Bai, Tao Zhang, Cheng-Gong Liao
Yun Wang, Shao-Kai Bai, Tao Zhang, Cheng-Gong Liao, Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi’an 710038, Shaanxi Province, China
Author contributions: Wang Y and Bai SK designed and performed the assay; Zhang T analyzed the data; Liao CG designed the study and prepared the manuscript.
Supported by the Social Talent Fund Supporting Scheme of Tangdu Hospital, No. 2021SHRC001.
Institutional review board statement: The study was approved by the Hospital Ethics Committee (202203-116).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Cheng-Gong Liao, PhD, Chief Physician, Department of Oncology, Tangdu Hospital, Air Force Medical University, No. 569 Xinsi Road, Xi’an 710038, Shaanxi Province, China.
Received: May 5, 2023
Peer-review started: May 5, 2023
First decision: July 9, 2023
Revised: July 21, 2023
Accepted: August 18, 2023
Article in press: August 18, 2023
Published online: September 15, 2023
Core Tip

Core Tip: MicroRNAs (miRNAs) have been implicated in almost all known cancer processes. Although many algorithms can predict target genes for miRNA, the exact regulatory relationships still need to be experimentally verified. In this study, we investigated the role of miR-363-3p in clonogenic survival, proliferation, and migration of colorectal cancer cells and interferon-induced transmembrane protein 1 (IFITM1) was identified as a direct target of miR-363-3p. These findings widen and deepen the understanding of the molecular function of miR-363-3p and IFITM1.