Clinical and Translational Research
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2023; 15(8): 1412-1423
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1412
Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma
Yun-Ji Xu, Hong-Jie He, Peng Wu, Wen-Bing Li
Yun-Ji Xu, Hong-Jie He, Peng Wu, Wen-Bing Li, Department of General Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Xu YJ was responsible for analyzing the data and composing the manuscript; He HJ and Wu P contributed to acquiring and analyzing data and reviewing the manuscript; Li WB contributed to conceiving and designing the present study; All authors read and approved the final manuscript and confirmed the authenticity of all the raw data.
Institutional review board statement: This study was approved by the Second Clinical College Committee of South China University.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: The data of this study are available upon reasonable request through the corresponding author at loverpig520@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Bing Li, PhD, Doctor, Department of General Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, No. 28 Changsheng West Road, Hengyang 421001, Hunan Province, China. loverpig520@163.com
Received: March 28, 2023
Peer-review started: March 28, 2023
First decision: May 17, 2023
Revised: May 30, 2023
Accepted: June 27, 2023
Article in press: June 27, 2023
Published online: August 15, 2023
Processing time: 135 Days and 4.8 Hours
Core Tip

Core Tip: Hepatocellular carcinoma (HCC) has very low overall survival. The discovery of a new biomarker related to prognosis would improve the prognosis of HCC. Cluster of differentiation 147 (CD147) is a novel transmembrane glycoprotein that is expressed in a wide variety of tumor cells and plays an important role in various stages of tumor development. In our study, we found that CD147 correlated with clinical characteristics and prognosis of HCC. Therefore, we suggest that CD147 can serve as a biomarker to predict the prognosis of HCC.