Clinical and Translational Research
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2023; 15(8): 1412-1423
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1412
Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma
Yun-Ji Xu, Hong-Jie He, Peng Wu, Wen-Bing Li
Yun-Ji Xu, Hong-Jie He, Peng Wu, Wen-Bing Li, Department of General Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Xu YJ was responsible for analyzing the data and composing the manuscript; He HJ and Wu P contributed to acquiring and analyzing data and reviewing the manuscript; Li WB contributed to conceiving and designing the present study; All authors read and approved the final manuscript and confirmed the authenticity of all the raw data.
Institutional review board statement: This study was approved by the Second Clinical College Committee of South China University.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: The data of this study are available upon reasonable request through the corresponding author at loverpig520@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Bing Li, PhD, Doctor, Department of General Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, No. 28 Changsheng West Road, Hengyang 421001, Hunan Province, China. loverpig520@163.com
Received: March 28, 2023
Peer-review started: March 28, 2023
First decision: May 17, 2023
Revised: May 30, 2023
Accepted: June 27, 2023
Article in press: June 27, 2023
Published online: August 15, 2023
Processing time: 135 Days and 4.8 Hours
ARTICLE HIGHLIGHTS
Research background

Hepatocellular carcinoma (HCC) has very low overall survival. Searching for a new biomarker related to prognosis will be helpful in improving the prognosis of HCC. Cluster of differentiation 147 (CD147) is a novel transmembrane glycoprotein that is expressed in a wide variety of tumor cells and plays an important role in various stages of tumor development.

Research motivation

CD147 is highly expressed in various tumors and is associated with prognosis.

Research objectives

To explore the pattern of CD147 expression and its applicability in the prognosis of HCC. To establish hazard ratios and probability points for predicting the prognosis of HCC by correlating CD147 expression with clinical characteristics. To determine if CD147 can be a reliable biomarker in HCC prognosis.

Research methods

Using The Cancer Genome Atlas and Gene Expression Omnibus databases, R language was used to analyze the expression of CD147 in HCC. The online website UALCAN was used to analyze the correlation between clinical characteristics and survival time of The Cancer Genome Atlas-Liver Hepatocellular Carcinoma and CD147 expression. Subsequently, time-dependent receiver operating characteristic curves were used to analyze the accuracy, sensitivity, and specificity of CD147 in HCC. Finally, univariate and multivariate Cox regression proportional hazards analyses of CD147 expression levels and clinical characteristics as prognostic factors of HCC were performed. Nomograms were used to establish probability points and predict prognosis.

Research results

CD147 was overexpressed in HCC, and the prognosis of HCC was significantly correlated with the clinical characteristics of HCC. The overexpression of CD147 showed poor prognosis and a hazard ratio of survival > 1 in HCC. Multivariate Cox analysis of CD147 patterns and pathological tumor-node-metastasis-stage showed significant differences. Nomograms showed CD147 can predict prognosis.

Research conclusions

CD147 is overexpressed and is associated with clinical characteristics in HCC. CD147 overexpressed in HCC has a poor prognosis. In addition, CD147 can predict the prognosis of HCC.

Research perspectives

Based on our study and the reports described previously, we theorize that CD147 may be used as a novel biological indicator to predict the prognosis of HCC.