Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2023; 15(5): 902-910
Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.902
Oral fruquintinib combined with tegafur-gimeracil-oteracil potassium for advanced colorectal cancer to obtain longer progression-free survival: A case report
Fan-Jie Qu, Shuang Wu, Yan Kong
Fan-Jie Qu, Shuang Wu, Yan Kong, Department of Oncology, Affiliated Dalian Third People’s Hospital of Dalian Medical University, Dalian 116033, Liaoning Province, China
Author contributions: Qu FJ, Wu S, and Kong Y were responsible for collecting data, analyzing data, and writing the article; Kong Y was responsible for guiding the writing and participating in the revision of the article; All authors read and approved the final manuscript.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yan Kong, MD, Professor, Department of Oncology, Affiliated Dalian Third People’s Hospital of Dalian Medical University, No. 40 Qianshan Road, Dalian 116033, Liaoning Province, China.
Received: January 26, 2023
Peer-review started: January 26, 2023
First decision: March 8, 2023
Revised: March 13, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: May 15, 2023
Core Tip

Core Tip: After the failure of second-line standard therapy, effective treatment options for metastatic colorectal cancer (CRC) are limited. Here, we describe a patient with CRC with multiple lung metastases. Disease progression occurred after oxaliplatin + 5-fluorouracil or capecitabine as first-line treatment and bevacizumab + irinotecan as second-line treatment. The patient received targeted therapy with fruquintinib and responded well for 12 mo. Progression-free survival was again achieved over 13.5 mo by continuing fruquintinib in combination with tegafur-gimeracil-oteracil potassium chemotherapy. This case detailed preliminary evidence showing that the combination of fruquintinib with tegafur-gimeracil-oteracil potassium resulted in longer progression-free survival in patients with CRC.