Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2023; 15(5): 731-756
Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.731
Exosomes in metastasis of colorectal cancers: Friends or foes?
Zheng Wu, Ze-Xuan Fang, Yan-Yu Hou, Bing-Xuan Wu, Yu Deng, Hua-Tao Wu, Jing Liu
Zheng Wu, Ze-Xuan Fang, Yan-Yu Hou, Jing Liu, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Bing-Xuan Wu, Yu Deng, Hua-Tao Wu, Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Wu Z contributed to this work; Fang ZX, Hou YY, Wu BX and Deng Y participated in the writing of the manuscript; Wu HT and Liu J reviewed the manuscript and contacted the journals; All authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China, No. 82273457; Natural Science Foundation of Guangdong Province, No. 2021A1515012180 and 2016A030312008; Special Grant for Key Area Programs of Guangdong Department of Education, No. 2021ZDZX2040; and Science and Technology Special Project of Guangdong Province, No. 210715216902829.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Liu, MD, PhD, Academic Research, Associate Professor, Research Scientist, Senior Scientist, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Received: December 7, 2022
Peer-review started: December 7, 2022
First decision: February 23, 2023
Revised: March 7, 2023
Accepted: April 4, 2023
Article in press: April 4, 2023
Published online: May 15, 2023
Processing time: 156 Days and 4.2 Hours
Core Tip

Core Tip: Exosomes, the extracellular vesicles function as connectors in communication between cancer cells and different components of the tumor microenvironment (TME). The miRNAs packaged into exosomes were derived from different sources and transported into the TME, performing oncogenesis or tumor-suppressor roles.