Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2023; 15(5): 713-730
Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.713
Intratumour microbiome of pancreatic cancer
Shi-Wei Guan, Quan Lin, Hai-Bo Yu
Shi-Wei Guan, Quan Lin, Hai-Bo Yu, Department of Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: All authors contributed to the original ideas and writing of this paper; Guan SW wrote the paper; Lin Q draw figures; Yu HB made critical revisions of this paper; all authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hai-Bo Yu, MD, Chief Doctor, Department of Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, No. 252 Baili East Road, Wenzhou 325000, Zhejiang Province, China.
Received: December 2, 2022
Peer-review started: December 2, 2022
First decision: January 16, 2023
Revised: January 26, 2023
Accepted: April 4, 2023
Article in press: April 4, 2023
Published online: May 15, 2023
Core Tip

Core Tip: Recently, with the development of high-throughput sequencing, tumour tissues, which were previously believed to be sterile, have been shown to harbor a low microbiome biomass. The intratumour microbiome is crucial for pancreatic ductal adenocarcinoma (PDAC) diagnosis, treatment, chemotherapy resistance, and immune response. Establishing an awareness of the biology of the tumour microbiome in PDAC supports the establishment of better strategies for PDAC. This review focuses on the possible origins of the microbiome, the localization, the interaction with the tumour microenvironment and the strategies for improving the outcomes of treatment. This review offers new perspectives for improving the prognosis of PDAC.