Opinion Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2023; 15(5): 700-712
Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.700
Restaging rectal cancer following neoadjuvant chemoradiotherapy
Dajana Cuicchi, Giovanni Castagna, Stefano Cardelli, Cristina Larotonda, Benedetta Petrello, Gilberto Poggioli
Dajana Cuicchi, Giovanni Castagna, Stefano Cardelli, Cristina Larotonda, Benedetta Petrello, Gilberto Poggioli, Department of Medical and Surgical Sciences, Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna 40138, Italy
Author contributions: Cuicchi D, Castagna G, Larotonda C, Cardelli S and Petrello B collected data, drafted the initial manuscript, and approved the final version to be submitted; Poggioli G reviewed and revised the manuscript, and approved the final version to be submitted.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dajana Cuicchi, MD, PhD, Surgeon, Department of Medical and Surgical Sciences, Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna 40138, Italy. dajana.cuicchi@aosp.bo.it
Received: December 22, 2022
Peer-review started: December 22, 2022
First decision: February 24, 2023
Revised: March 1, 2023
Accepted: March 29, 2023
Article in press: March 29, 2023
Published online: May 15, 2023
Core Tip

Core Tip: Correct tumour restaging is pivotal for identifying the most personalised surgical treatment for patients with locally advanced rectal cancer undergoing neoadjuvant therapy; it allows avoidance of both poor oncological outcomes and overtreatment. However, there are no guidelines regarding the definition, timing, and diagnostic techniques to be carried out. This study provides the most up-to-date evidence on this topic and the outstanding issues worthy of future research.