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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2023; 15(4): 632-643
Published online Apr 15, 2023. doi: 10.4251/wjgo.v15.i4.632
Published online Apr 15, 2023. doi: 10.4251/wjgo.v15.i4.632
Clinical implications and perspectives of portal venous circulating tumor cells in pancreatic cancer
Sung Woo Ko, Seung Bae Yoon, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea
Seung Bae Yoon, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, Seoul 03312, South Korea
Author contributions: Ko SW and Yoon SB contributed equally to the conception, design, and literature search; Ko SW drafted the manuscript and prepared the tables; Yoon SB modified and revised the manuscript.
Supported by the National Research Foundation of Korea , No. NRF-2021 R1F1A1062255 .
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seung Bae Yoon, MD, PhD, Associate Professor, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, 1021, Tongil Ro, Eunpyeong-gu, Seoul 03312, South Korea. sbyoon@catholic.ac.kr
Received: December 24, 2022
Peer-review started: December 24, 2022
First decision: January 30, 2023
Revised: February 10, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 15, 2023
Peer-review started: December 24, 2022
First decision: January 30, 2023
Revised: February 10, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 15, 2023
Core Tip
Core Tip: Circulating tumor cells (CTCs) are emerging minimally invasive biomarkers for evaluating tumor characteristics; however, limited CTCs are detected in the peripheral blood. Portal venous blood, which does not undergo hepatic filtration, can theoretically harbor a large number of CTCs and can be safely assessed using endoscopic ultrasound. The efficacy of CTCs in portal venous blood have shown encouraging results (i.e., higher detection rate and better prediction of prognosis). Here, we provide an overview of CTCs in portal venous blood in the clinical context and future perspectives to enhance the role of portal CTCs as a valid biomarker in pancreatic cancer.