Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2023; 15(3): 546-561
Published online Mar 15, 2023. doi: 10.4251/wjgo.v15.i3.546
Mitophagy-related gene signature predicts prognosis, immune infiltration and chemotherapy sensitivity in colorectal cancer
Jin-Sen Weng, Jie-Ping Huang, Wei Yu, Jun Xiao, Fang Lin, Kang-Ni Lin, Wei-Dong Zang, Yong Ye, Jing-Ping Lin
Jin-Sen Weng, Fang Lin, Kang-Ni Lin, Yong Ye, Jing-Ping Lin, Critical Care Medicine, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, Fujian Province, China
Jie-Ping Huang, Department of Emergency, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Wei Yu, Clinical Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, Fujian Province, China
Jun Xiao, Wei-Dong Zang, Gastrointestinal Surgery Department, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, Fujian Province, China
Author contributions: Weng JS, Huang JP, and Yu W contributed equally to this work; Lin JP and Ye Y had the idea for this study; Weng JS, Huang JP, and Yu W supervised the acquisition of the data; Xiao J and Zang WD undertook the statistical analysis; Lin F, Lin KN, and Zang WD provided statistical advice; all authors contributed to interpretation of the results; Weng JS, Huang JP, and Yu W wrote the article and other authors contributed to the content; all authors approved the final version of the manuscript, including the authorship list.
Institutional review board statement: The study was reviewed and approved by the Fujian Cancer Ethics Committee (Approval No. K2023-030-01).
Informed consent statement: All the data were downloaded from GEO and TCGA database, thus the informed consent statement is not applicable in this study.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: Source data and reagents are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Ping Lin, MD, Doctor, Critical Care Medicine, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou 350014, Fujian Province, China. ljpccm@163.com
Received: November 20, 2022
Peer-review started: November 20, 2022
First decision: December 10, 2022
Revised: December 23, 2022
Accepted: February 23, 2023
Article in press: February 23, 2023
Published online: March 15, 2023
Processing time: 114 Days and 13.6 Hours
Core Tip

Core Tip: We for the first time revealed the biological roles of mitophagy-related genes in the immune infiltration, and its prediction of patients’ prognosis and chemotherapy response in colorectal cancer. These novel findings would provide new insight into the therapeutic management of colorectal cancer patients.