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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2023; 15(2): 225-239
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.225
Role of ferroptosis in colorectal cancer
Ya-Qi Song, Xiao-Dan Yan, Yi Wang, Zhen-Zhen Wang, Xin-Li Mao, Li-Ping Ye, Shao-Wei Li
Ya-Qi Song, Li-Ping Ye, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai 317000, Zhejiang Province, China
Xiao-Dan Yan, Yi Wang, Zhen-Zhen Wang, Xin-Li Mao, Li-Ping Ye, Shao-Wei Li, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Li-Ping Ye, Shao-Wei Li, Institute of Digestive Disease, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Shao-Wei Li, Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Author contributions: Song YQ, Ye LP, Mao XL, and Wang Y drafted the manuscript; Wang ZZ, Yan XD, and Li SW contributed to the editing of the manuscript; All authors contributed to the article and approved the submitted version.
Supported by Medical Health Science and Technology Project of Zhejiang Province, No. 2021PY083; Program of Taizhou Science and Technology Grant, No. 22ywb09 and No. 1901ky18; Key Technology Research and Development Program of Zhejiang Province, No. 2019C03040; Major Research Program of Taizhou Enze Medical Center Grant, No. 19EZZDA2.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Wei Li, PhD, Associate Professor, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150 Ximen Street, Linhai 317000, Zhejiang Province, China. li_shaowei81@hotmail.com
Received: September 19, 2022
Peer-review started: September 19, 2022
First decision: December 1, 2022
Revised: December 15, 2022
Accepted: January 9, 2023
Article in press: January 9, 2023
Published online: February 15, 2023
Core Tip

Core Tip: The prognosis of patients with advanced colorectal cancer is still poor, largely due to resistance to anticancer drugs. Ferroptosis is a novel form of non-apoptotic cell death, mainly characterized by abnormal iron metabolism and the excessive accumulation of lipid peroxidation. Studies have shown that ferroptosis can participate in the process of colorectal cancer (CRC) through the accumulation of lipid peroxides, inhibition of the System Xc−, disruption of the glutathione/glutathione peroxidase 4 balance, imbalance of iron homeostasis, and mediation of the P53 pathway. Induction of ferroptosis can reverse the resistance of anticancer drugs and improve the prognosis of CRC patients.