Song YQ, Yan XD, Wang Y, Wang ZZ, Mao XL, Ye LP, Li SW. Role of ferroptosis in colorectal cancer. World J Gastrointest Oncol 2023; 15(2): 225-239 [PMID: 36908317 DOI: 10.4251/wjgo.v15.i2.225]
Corresponding Author of This Article
Shao-Wei Li, PhD, Associate Professor, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150 Ximen Street, Linhai 317000, Zhejiang Province, China. li_shaowei81@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2023; 15(2): 225-239 Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.225
Role of ferroptosis in colorectal cancer
Ya-Qi Song, Xiao-Dan Yan, Yi Wang, Zhen-Zhen Wang, Xin-Li Mao, Li-Ping Ye, Shao-Wei Li
Ya-Qi Song, Li-Ping Ye, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai 317000, Zhejiang Province, China
Xiao-Dan Yan, Yi Wang, Zhen-Zhen Wang, Xin-Li Mao, Li-Ping Ye, Shao-Wei Li, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Li-Ping Ye, Shao-Wei Li, Institute of Digestive Disease, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Shao-Wei Li, Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Author contributions: Song YQ, Ye LP, Mao XL, and Wang Y drafted the manuscript; Wang ZZ, Yan XD, and Li SW contributed to the editing of the manuscript; All authors contributed to the article and approved the submitted version.
Supported byMedical Health Science and Technology Project of Zhejiang Province, No. 2021PY083; Program of Taizhou Science and Technology Grant, No. 22ywb09 and No. 1901ky18; Key Technology Research and Development Program of Zhejiang Province, No. 2019C03040; Major Research Program of Taizhou Enze Medical Center Grant, No. 19EZZDA2.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Wei Li, PhD, Associate Professor, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150 Ximen Street, Linhai 317000, Zhejiang Province, China. li_shaowei81@hotmail.com
Received: September 19, 2022 Peer-review started: September 19, 2022 First decision: December 1, 2022 Revised: December 15, 2022 Accepted: January 9, 2023 Article in press: January 9, 2023 Published online: February 15, 2023 Processing time: 148 Days and 15.7 Hours
Abstract
Colorectal cancer (CRC) is the second deadliest cancer and the third-most common malignancy in the world. Surgery, chemotherapy, and targeted therapy have been widely used to treat CRC, but some patients still develop resistance to these treatments. Ferroptosis is a novel non-apoptotic form of cell death. It is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer drugs. This review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC.
Core Tip: The prognosis of patients with advanced colorectal cancer is still poor, largely due to resistance to anticancer drugs. Ferroptosis is a novel form of non-apoptotic cell death, mainly characterized by abnormal iron metabolism and the excessive accumulation of lipid peroxidation. Studies have shown that ferroptosis can participate in the process of colorectal cancer (CRC) through the accumulation of lipid peroxides, inhibition of the System Xc−, disruption of the glutathione/glutathione peroxidase 4 balance, imbalance of iron homeostasis, and mediation of the P53 pathway. Induction of ferroptosis can reverse the resistance of anticancer drugs and improve the prognosis of CRC patients.
