Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2023; 15(1): 36-54
Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.36
Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review
Yi-Lin Zhong, Peng-Qian Wang, Dan-Li Hao, Feng Sui, Feng-Bin Zhang, Bing Li
Yi-Lin Zhong, Peng-Qian Wang, Dan-Li Hao, Feng Sui, Bing Li, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Feng-Bin Zhang, Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Zhong YL and Wang PQ contributed equally to this study; Li B and Wang PQ conceptualized the study; Wang PQ and Zhong YL wrote the initial manuscript; Hao DL, Sui F, and Zhang FB participated in the preparation of key figures and tables; all authors were involved in the critical revision
Supported by the National Natural Science Foundation of China, No. 81904064; Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences, No.CI2021A03804 and No. CI2021A05052; and Fundamental Research Funds for the Central Public Welfare Research Institutes, No. ZZ14-YQ-023, No. ZXKT21017, and No. ZXKT21024.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Li, MD, Associate Research Scientist, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China. libingtcm@163.com
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: November 15, 2022
Revised: December 6, 2022
Accepted: December 27, 2022
Article in press: December 27, 2022
Published online: January 15, 2023
Processing time: 111 Days and 23.7 Hours
Core Tip

Core Tip: Precancerous lesions are precursors of gastric cancer (GC). The molecular mechanism of the transformation of precancerous lesions into GC remains unclear. This article reviews the mechanism of traditional Chinese medicine in the treatment of precancerous lesions and GC, and describes the relationship between the molecular mechanisms of Chinese medicine in treating these two pathological stages, providing a research idea for blocking GC progression through the gastric precancerous lesion stage.