Zhong YL, Wang PQ, Hao DL, Sui F, Zhang FB, Li B. Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review. World J Gastrointest Oncol 2023; 15(1): 36-54 [PMID: 36684050 DOI: 10.4251/wjgo.v15.i1.36]
Corresponding Author of This Article
Bing Li, MD, Associate Research Scientist, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China. libingtcm@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yi-Lin Zhong, Peng-Qian Wang, Dan-Li Hao, Feng Sui, Bing Li, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Feng-Bin Zhang, Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Zhong YL and Wang PQ contributed equally to this study; Li B and Wang PQ conceptualized the study; Wang PQ and Zhong YL wrote the initial manuscript; Hao DL, Sui F, and Zhang FB participated in the preparation of key figures and tables; all authors were involved in the critical revision
Supported bythe National Natural Science Foundation of China, No. 81904064; Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences, No.CI2021A03804 and No. CI2021A05052; and Fundamental Research Funds for the Central Public Welfare Research Institutes, No. ZZ14-YQ-023, No. ZXKT21017, and No. ZXKT21024.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Li, MD, Associate Research Scientist, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China. libingtcm@163.com
Received: September 20, 2022 Peer-review started: September 20, 2022 First decision: November 15, 2022 Revised: December 6, 2022 Accepted: December 27, 2022 Article in press: December 27, 2022 Published online: January 15, 2023 Processing time: 111 Days and 23.7 Hours
Abstract
Gastric cancer (GC) is a common gastrointestinal tumor. Gastric precancerous lesions (GPL) are the last pathological stage before normal gastric mucosa transforms into GC. However, preventing the transformation from GPL to GC remains a challenge. Traditional Chinese medicine (TCM) has been used to treat gastric disease for millennia. A series of TCM formulas and active compounds have shown therapeutic effects in both GC and GPL. This article reviews recent progress on the herbal drugs and pharmacological mechanisms of TCM in preventing the transformation from GPL to GC, especially focusing on anti-inflammatory, anti-angiogenesis, proliferation, and apoptosis. This review may provide a meaningful reference for the prevention of the transformation from GPL to GC using TCM.
Core Tip: Precancerous lesions are precursors of gastric cancer (GC). The molecular mechanism of the transformation of precancerous lesions into GC remains unclear. This article reviews the mechanism of traditional Chinese medicine in the treatment of precancerous lesions and GC, and describes the relationship between the molecular mechanisms of Chinese medicine in treating these two pathological stages, providing a research idea for blocking GC progression through the gastric precancerous lesion stage.
