Wu WX, Zhang DK, Chen SX, Hou ZY, Sun BL, Yao L, Jie JZ. Prognostic impact of tumor deposits on overall survival in colorectal cancer: Based on Surveillance, Epidemiology, and End Results database. World J Gastrointest Oncol 2022; 14(9): 1699-1710 [PMID: 36187391 DOI: 10.4251/wjgo.v14.i9.1699]
Corresponding Author of This Article
Jian-Zheng Jie, MD, Doctor, Department of Colorectal Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. dakuizhang2021@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2022; 14(9): 1699-1710 Published online Sep 15, 2022. doi: 10.4251/wjgo.v14.i9.1699
Prognostic impact of tumor deposits on overall survival in colorectal cancer: Based on Surveillance, Epidemiology, and End Results database
Wen-Xiao Wu, Da-Kui Zhang, Shao-Xuan Chen, Zhi-Yong Hou, Bai-Long Sun, Li Yao, Jian-Zheng Jie
Wen-Xiao Wu, Jian-Zheng Jie, Department of Surgery, Graduate School of Peking Union Medical College, Beijing 100730, China
Wen-Xiao Wu, Da-Kui Zhang, Shao-Xuan Chen, Zhi-Yong Hou, Bai-Long Sun, Li Yao, Jian-Zheng Jie, Department of Colorectal Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Jie JZ and Wu WX designed the study; Wu WX, Zhang DK and Chen SX acquired data; Wu WX and Hou ZY analyzed and interpreted data; Wu WX, Sun BL and Yao L drafted the manuscript.
Supported bythe Scientific and Technological Project of Qinghai Province, China, No. 2015-ZJ-742.
Institutional review board statement: The current study relied on the SEER cancer registry, which did not require further approval of institutional review aboard.
Informed consent statement: This study was exempt from informed consent.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Zheng Jie, MD, Doctor, Department of Colorectal Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. dakuizhang2021@126.com
Received: April 19, 2022 Peer-review started: April 19, 2022 First decision: May 11, 2022 Revised: May 18, 2022 Accepted: July 26, 2022 Article in press: July 26, 2022 Published online: September 15, 2022
Core Tip
Core Tip: We evaluated the predictive value of tumor deposits (TDs) for overall survival (OS) in patients with colorectal cancer based on a collection of 103755 patients derived from Surveillance, Epidemiology, and End Results database, including TD-negative and TD-positive subpopulations with Cox proportional hazard model. The sensitivity analyses were performed to detect outcome robustness. TD was an independent prognostic factor for OS. We also performed exploratory analysis to evaluate the effect of TD addition to the lymph node metastases count in tumor, node and metastasis-stage III subpopulations. The outcomes of subgroup analysis investigating the different risk factor profiles indicated that TDs may affect survival through more than one approach.
